Clinical Observation on Chaihu Huaji Decoction in Improving Postembolization Syndrome of Hepatocellular Carcinoma following Transcatheter Arterial Chemoembolization
Objective:To evaluate the efficacy of Chaihu Huaji Decoction in improving postembolization syn-drome of hepatocellular carcinoma following transcatheter arterial chemoembolization(TACE).Methods:Patients who met the enrollment requirements were selected.They were firstly stratified according to the clinical stages of liver cancer,and were divided into stage Ⅰ b,stage Ⅱ a,stage Ⅱb and stage Ⅲa subgroups,and then randomly di-vided into the treatment group and control group according to random number table method.Finally,all the treat-ment groups in the four subgroups were combined with the control group to form the final treatment group and con-trol group in this study.The treatment group was treated with basic treatment combined with Chaihu Huaji Decoc-tion,while the control group was treated with basic treatment only,and the treatment cycle was 7 days.There were 50 effective cases in the treatment group and the control group respectively.The TCM pattern scores,liver func-tion,alpha-fetoprotein(AFP),blood routine,renal function and electrolytes were compared between the two groups before and after treatment,and the TCM pattern scores of each subgroup were analyzed in stratified ways.Re-sults:The total effective rate of TCM syndrome in the treatment group was significantly higher than that in the control group(P＜0.05).Compared between the two groups,the pattern scores and total pattern scores of fever,nau-sea and vomiting,dry mouth,bitter mouth,loose stool,and poor appetite in the treatment group were significantly lower than those in the control group(P＜0.05).On the 7th day after surgery,the levels of alanine aminotransferase(ALT)and aspartate aminotransferase(AST)in the treatment group were significantly lower than those in the con-trol group(P＜0.05).On the 28th day after operation,the TBIL in the treatment group was significantly lower than that in the control group(P＜0.05).There was no obvious difference in AFP between two group(P＞0.05).There were no significant differences in hemoglobin(HGB),red blood cell count(RBC),white blood cell count(WBC),platelet count(PLT),serum creatinine(CR),serum potassium(K+)and serum sodium(Na+)between the two groups at each stage(P＞0.05).After treatment,the total score of TCM syndrome in each stage of the treatment group was significantly lower than that of the control group at the same stage(P＜0.05),and the total score of TCM syndrome in stage Ⅲ a of the treatment group decreased the most obvious,and the number of symptoms with significant im-provement in stage Ⅰ b in the treatment group was the most.Conclusion:Chaihu Huaji Decoction has a definite effect on the treatment of postembolization syndrome of hepatocellular carcinoma following TACE,and can signifi-cantly improve TCM syndromes and liver function.The number of symptoms improved in stage Ⅰ b is the most,and the degree of improvement in stage Ⅲ a is the most obvious.
NETL
NSTL
万方数据
