Network Pharmacology Study on the Molecular Mechanisms of Portulaca Oleracea in the Treatment of Atopic Dermatitis
Objective:To explore the molecular mechanism of Portulaca oleracea in the treatment of atopic der-matitis with network pharmacology and molecular docking technology.Methods:The chemical constituents of Por-tulaca oleracea were retrieved from TCMSP database.Pubchem database and Swisstargetpredicton database were searched for the action targets of the chemical components of Portulaca oleracea,simultaneously for the targets of atopic dermatitis and related allergic diseases from Genecards database,then calculated the common targets of the above two groups of data.A series of calculations were carried out,including GO enrichment and KEGG,and mo-lecular docking prediction was conducted with Discovery Studio.HaCaT cells and RAW264.7 cells,which were commonly used in atopic dermatitis experiments,were selected for the experiment.Results:There were 48 kinds of effective chemical constituents in Portulaca oleracea.There were 20 common chemical targets between Portu-laca oleracea and atopic dermatitis.The GO enrichment results showed that there were 101 items related to biologi-cal functions,18 items related to cell components,and 28 items related to molecular functions.There were 75 sig-nal pathways enriched by KEGG.The molecular docking prediction map showed that the docking effect of drug components and target protein molecules would be good.Conclusion:Portulaca oleracea can treat atopic dermati-tis through multiple target pathways.
NETL
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