Study on Correlation Between 4D Flow MRI Hemodynamic Parameters and Traditional Chinese Medi-cine Syndromes in Patients with Cirrhosis
Objective:To investigate the correlation between 4D flow MRI hemodynamic parameters and TCM syndromes in cirrhosis.Methods:A total of 118 patients were categorized into 5 syndrome types according to TCM diagnostic criteria,i.e.,liver qi stagnation syndrome,interior dampness-heat syndrome,liver-kidney yin de-ficiency,spleen-kidney yang deficiency,blood stasis obstruction,respectively.All patients underwent portal vein 4D flow MRI.The distribution of patients with different types of liver cirrhosis was counted,and the hemodynamic parameters of the portal vein system(main portal vein,splenic vein,superior mesenteric vein)were observed,in-cluding blood flow,flow velocity,wall shear force,etc.The differences in portal hemodynamics among patients with different TCM syndromes was compared.Results:The compensatory phase of cirrhosis were mainly liver qi stagna-tion syndrome,interior dampness-heat syndrome.The decompensatory phase of cirrhosis were mainly spleen-kid-ney yang deficiency and blood stasis obstruction.Grade A was mainly characterized by liver qi stagnation syn-drome and interior dampness-heat syndrome,while grade B and C were mainly characterized by blood stasis ob-struction.The main portal vein and spleen vein blood flow in cirrhosis with blood stasis obstruction were signifi-cantly higher than those in cirrhosis with liver qi stagnation syndrome,interior dampness-heat syndrome(P＜0.05).The main portal vein blood flow in cirrhosis with spleen-kidney yang deficiency was significantly higher than those in cirrhosis with liver qi stagnation syndrome(P＜0.05).The main portal vein flow velocity and shear force in cirrhosis with blood stasis obstruction were lower than those in cirrhosis with liver qi stagnation syndrome and interior dampness-heat syndrome.Conclusion:There is a certain correlation between TCM syndrome differen-tiation and portal vein hemodynamics in cirrhosis,and 4D flow MRI can provide hemodynamic reference for TCM dialectics of cirrhosis.
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