Effect of Liangxue Jiedu Lishui Decoction Combined with Plasma Exchange on Prognosis of Patients with Hepatitis B Related Chronic Acute Liver Failure
Objective:To investigate the effect of Liangxue Jiedu Lishi Decoction combined with plasma ex-change on the prognosis of patients with hepatitis B-related chronic acute liver failure(HBV-ACLF).Methods:A total of 76 patients with HBV-ACLF were divided into the control group and observation group with 38 patients respectively according to random number table method.The control group was treated with plasma exchange,and the observation group was combined with the prescription of Liangxue Jiedu Lishi Decoction on the basis of the con-trol group.Three weeks after treatment,TCM syndrome scores,liver function[albumin(ALB),glutamic-pyruginase(ALT),glutamic-oxalic aminotransferase(AST),total bilirubin(TBil)],inflammatory factors[tumor necrosis factor(TNF-α),interleukin-6(IL-6),interleukin-10(IL-10)]and T lymphocyte subsets before and after treatment were compared between the two groups.The efficacy,safety and prognosis of the patients were evaluated.Results:After treatment,the TCM syndrome scores of both groups were decreased,and the scores of jaundice,high fever with thirst,red tongue with yellow coating,yellowish urine,and fatigue in the observation group were lower than those of the control group(P＜0.05).After treatment,ALB,IL-10,CD4+,CD4+/CD8+were increased in both groups,while ALT,AST,TBil,TNF-α,IL-6 and CD8+were decreased(P＜0.05),and the improvement of these in-dexes in observation group was greater than that in control group(P＜0.05).The total effective rate of observation group was 92.11％,which was higher than 73.68％of control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion:The treatment of HBV-ACLF with Liangxue Jiedu Lishi Decoction combined with plasma therapy is effective,can significantly relieve the clinical symptoms of patients,regulate the liver function and immune function,inhibit the inflammatory response,promote the prognosis,and is relatively safe.
Hepatitis B-related chronic plus acute liver failureSyndrome of blazing heat-toxinLiangxue Jiedu Lishi DecoctionPlasma exchangeInflammatory factorsT lymphocytesprognosis
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