Effects of Modified Laifu Decoction on Serum H-FABP,cTnⅠ,and NT-proBNP Expression in Patients with Acute Exacerbation of Chronic Heart Failure
Objective:To evaluate the clinical efficacy of modified Laifu Decoction combined with conventional therapy in the treatment of acute exacerbation of chronic heart failure(CHF).Methods:Totally 100 patients were randomly divided into the control group and observation group,with 50 cases in each group.The control group re-ceived comprehensive treatment with western medicine,while the observation group was given modified Laifu De-coction on the basis of the control group,one dose/day,and continuously for four weeks.Echocardiographic param-eters(LVEF,SV,CO and CI)were compared before and after treatment;myocardial injury biomarkers(NT-proB-NP,cTnⅠ,H-FABP and GAL-3)levels were measured before and after treatment;6-minute walk test distance(6 MWT),yang deficiency and blood stasis syndrome,NYHA functional classification and resting heart rate were as-sessed before and after treatment;MSAS-HF and MLHFQ were assessed before and after treatment;and the over-all response rate was compared after treatment.Results:After treatment,echocardiographic parameters(LVEF,SV,CO and CI)increased in both groups(P＜0.05),and the observation group was higher than the control group(P＜0.05);after treatment,NT-proBNP,cTnⅠ,H-FABP and GAL-3 levels decreased in both groups(P＜0.05),and the observation group was lower than the control group(P＜0.05).After treatment,the scores of all dimensions and to-tal score of MSAS-HF scale decreased in the two groups(P＜0.05),the scores of all dimensions and total score of MLHFQ scale decreased in the two groups(P＜0.05),the main symptoms and total scores of yang deficiency and blood stasis syndrome decreased in the two groups,and the above indicators in the observation group were lower than those in the control group(P＜0.05).After treatment,6 MWT increased(P＜0.05)and resting heart rate de-creased in both groups(P＜0.05),and were observed to be significant(P＜0.05).The total effective rate in the ob-servation group was significantly higher than that in the control group(P＜0.05).Conclusion:The combination of modified Laifu Decoction and conventional therapy can protect myocardial injury,reduce clinical symptoms,signs and TCM syndromes related to heart failure,improve heart function,enhance the quality of life and exercise endur-ance in the acute exacerbation stage of CHF.The clinical efficacy is better than that of conventional western medi-cine treatment.
Chronic heart failureAcute exacerbation periodModified Laifu DecoctionYang deficiency and blood stasis syndromeQuality of lifeBiomarkers of myocardial injury
NETL
NSTL
万方数据
