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健神利水方治疗急性脑出血的临床观察

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目的 观察健神利水方对急性(自发性)脑出血患者血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)的影响及临床疗效.方法 90例患者随机分为观察组与对照组,两组均采取西医常规治疗,观察组加予健神利水方治疗,治疗观察期为4周,观察两组入院24 h和治疗7、14、28d的格拉斯哥昏迷指数(GCS)评分、神经功能缺损量表(NIHSS)评分及TNF-α、IL-6的变化,同时评估两组的临床疗效.结果 观察组总有效率为81.39%,高于对照组的72.09%(P<0.05);随着治疗时间的延长,两组NIHSS评分、血清TNF-α、IL-6水平均逐步下降(P<0.05),GCS评分逐步上升,观察组的NIHSS及血清IL-1、IL-6水平低于对照组(P<0.05),观察组的GCS评分高于对照组(P<0.05).结论 健神利水方可改善急性脑出血患者意识障碍程度和神经功能缺损,有助于提高临床疗效.
Clinical Observation of Jianshen Lishui Decoction in Treating Acute Cerebral Hemorrhage
Objective:To observe the effect of Jianshen Lishui Decoction on serum TNF-α and IL-6 in patients with acute(spontaneous)cerebral hemorrhage and its clinical curative effect.Methods:A total of 90 patients were randomly divided into the observation group and control group.Both groups were treated with routine western medicine,while the observation group was treated with Jianshen Lishui Decoction for 4 weeks.The changes of Glasgow Coma Scale(GCS),National Institutes of Health Stroke Scale(NIHSS),TNF-α and IL-6 of the two groups at 24 hours after admission and 7,14 and 28 days after treatment were studied,the correlation of TNF-α,IL-6 with GCS and NIHSS was analyzed.The clinical effects of the two groups were evaluated.Results:The total effective rate of the observation group was 81.39%,which was higher than 72.09%of the control group(P<0.05);with the extension of treatment time,the NIHSS score,serum TNF-α and IL-6 decreased gradually(P<0.05),the GCS score increased gradually.The NIHSS and serum IL-1,IL-6 in the observation group were lower than those in the control group(P<0.05),the GCS score in the observation group was higher than that in the control group(P<0.05).Conclusion:Jianshen Lishui Decoction can improve the degree of consciousness disturbance and nerve function defect in patients with acute cerebral hemorrhage,which is helpful to improve the clinical efficacy.

Cerebral hemorrhageJianshen Lishui DecoctionTNF-αIL-6Clinical efficacy

廖美容、高玉广、黄德庆、刘泰、马玉娟、庞东林

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广西壮族自治区桂林市中医医院,广西 桂林 541002

广西中医药大学第一附属医院,广西南宁 530022

脑出血 健神利水方 肿瘤坏死因子-α 白细胞介素-6 临床疗效

广西教育厅高等学校中青年教师科研基础能力提升项目广西中医药局自筹经费科研课题

2020KY07015GZZC2020036

2024

中国中医急症
中华中医药学会

中国中医急症

CSTPCD
影响因子:1.144
ISSN:1004-745X
年,卷(期):2024.33(6)
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