Clinical Observation on Auricular Seed Embedding Combined with Dingxuan Granules in the Treatment of Peripheral Vertigo
Objective:To observe the clinical efficacy and safety of auricular seed embedding combined with Dingxuan Granules in treating peripheral vertigo.Methods:88 patients with peripheral vertigo were randomly di-vided into a control group and a treatment group(44 cases each)using computer-generated randomization.Both groups received routine western medical treatments for anti-dizziness,anti-emetic,and circulation improvement.The control group was further administered Dingxuan Granules orally,while the treatment group,in addition to the control regimen,received auricular seed embedding based on syndrome differentiation.Clinical efficacy,DHI and ADL scores before and after treatment,mean blood flow velocity(VM)and resistivity index(RI)of the basilar ar-tery,serum levels of nitric oxide(NO),neuropeptide Y(NPY),and endothelin-1(ET-1),adverse reactions,and re-currence rates were observed in both groups.Results:After treatment,the total effective rate in the treatment group was significantly higher than in the control group(P<0.05).The treatment group showed more decrease in DHI scores(P<0.05)and more increase in ADL scores(P<0.05)compared with the control group.The VM of the basilar artery was significantly faster in the treatment group(P<0.05),and the RI was significantly lower(P<0.05)than in the control group.No significant differences were found in NPY levels between the two groups be-fore and after treatment(P>0.05),but the NO level was significantly higher in the treatment group(P<0.05).ET-1 levels decreased more significantly in the treatment group(P<0.05).Neither group reported adverse reactions during treatment,and there was no significant difference in recurrence rates within the first half-year follow-up(P>0.05).Conclusion:Auricular seed embedding combined with Dingxuan Granules shows significant efficacy in treating peripheral vertigo,which can regulate NO and ET-1 levels,increase the mean blood flow velocity of the basilar artery,reduce the resistivity index,improve clinical symptoms,and display high safety,thus it is worth of clinical promotion.