Clinical Study on Modified Baihu plus Guizhi Decoction in the Treatment of Knee Osteoarthritis with Syndrome of Damp-heat Stagnation
Objective:To investigate the efficacy of Modified Baihu plus Guizhi Decoction in the treatment of knee osteoarthritis(KOA)with syndrome of damp-heat stagnation.Methods:A total of 100 KOA patients with syndrome of damp-heat stagnation were divided into treatment group and control group by random number table method(50 cases in each).The control group was given conventional western medicine;patients in the treatment group were added with Modified Baihu plus Guizhi Decoction.Both groups were treated for 2 weeks.The treatment effects,scores of Western Ontario and McMaster University(WOMAC)osteoarthritis index and visual analogue scale(VAS),and serum levels of interleukin(IL)-1β,tumor necrosis factor(TNF)-α,matrix metalloproteinase(MMP)-13 were compared between the two groups.Results:After treatment,the total effective rate of the treat-ment group(96.00％)was significantly higher than that of the control group(80.00％)(P＜0.05).After 1 and 2 weeks of treatment,WOMAC scores in two groups were significantly decreased,and those in the treatment group were more significantly decreased(P＜0.05).After treatment,the VAS scores at activity and rest were significantly decreased in both groups,and more significantly in the treatment group(P＜0.05).After treatment,serum levels of IL-1β,TNF-α and MMP-13 were significantly decreased in two groups,and more significantly in treatment group(P＜0.05).Conclusion:Modified Baihu plus Guizhi Decoctionin the treatment of KOA with syndrome of damp-heat stagnation is evident,which can improve the symptoms and signs,reduce pain,and down-regulate serum lev-els of IL-1β,TNF-α,and MMP-13.
Knee osteoarthritisBaihu plus Guizhi DecoctionInterleukin-1βTumor necrosis factor-αMatrix metalloproteinase-13Syndrome of damp-heat stagnation
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