Correlation Analysis of TCM Pattern Elements and Acute Exacerbation of Chronic Obstructive Pulmonary Disease in High Altitude Area
Objective:To explore the correlation between TCM pattern elements and demographic characteris-tics and clinical data in acute exacerbation of chronic obstructive pulmonary disease(COPD)in high altitude area.Methods:A total of 634 in-patients in the Respiratory Department of Qinghai Hospital of TCM from October 2020 to September 2021 were selected.The data of patients were collected,and TCM pattern elements differentia-tion was performed.Results:There was a negative correlation between TCM sputum pattern element with serum hemoglobin(Hb)[OR=0.984,95％CI(0.977～0.992),P＜0.001].There were positive correlations between TCM phlegm-retention pattern element with age[OR=1.041,95％Cl(1.004～1.081),P=0.031],AE frequency[OR=1.288,95％CI(1.032～1.608),P=0.025],AE time[OR=1.036,95％CI(1.009～1.064),P=0.010],troponin[OR=1.015,95％CI(1.003～1.028),P=0.014]and IgM[OR=2.655,95％CI(1.317～5.352),P=0.006].There were nega-tive correlations between TCM turbid phlegm pattern element and AE time[OR=0.918,95％CI(0.857～0.984),P=0.016],Hb[OR=0.967,95％CI(0.947～0.987),P=0.038],positive correlation with blood oxygen saturation(SaO2)[OR=1.088,95％CI(1.005～1.179),P＜0.002],C3[OR=21.177,95％CI(2.12～211.517),P=0.009].There were negative correlations between TCM stasis pattern element and mMRC(4)[OR=0.127,95％CI(0.019～0.835),P=0.032]and PLT[OR=0.995,95％CI(0.991～0.998),P=0.005],positive correlations with PaCO2[OR=1.048,95％CI(1.002～1.096),P=0.039],Hb[OR=1.018,95％CI(1.008～1.027),P＜0.001].There were positive correlations between TCM phlegm-damp pattern element and Hb[OR=1.022,95％CI(1.006～1.039),P=0.007],procalcitonin(PCT)[OR=1.802,95％CI(1.056～3.076),P=0.031].Conclusion:The TCM pattern elements of acute exacerba-tion of COPD is sputum＞stasis＞heat＞phlegm-retention＞turbid phlegm＞phlegm-damp,and the main TCM sputum pattern elements were sputum and stasis.The older the age,the more times of AE,the longer the time of AE,the higher troponin and IgM,there is more probability of pattern element of phlegm-retention.With SaO2 and C3 increased,there is more possibility of pattern element of turbid phlegm.With PaCO2 and Hb increased,there is more possibility of pattern element of stasis.With Hb and PCT increased,there is more probability of pattern ele-ment of phlegm-damp.
Chronic obstructive pulmonary diseaseAcute exacerbation TCM excessiveness pattern elementsSyndrome element disease syndromeHigh altitude area
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