首页|脓毒性心肌病"虚气流滞"中医病机及"炎症-线粒体损伤"恶性循环假说

脓毒性心肌病"虚气流滞"中医病机及"炎症-线粒体损伤"恶性循环假说

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脓毒性心肌病是脓毒症引起的急性可逆性心功能障碍,病理机制复杂.本研究在王永炎院士创新性提出"虚气流滞"病机理论的影响下,剖析了脓毒性心肌病"虚气流滞"病机,同时基于现代研究成果总结脓毒性心肌病"炎症-线粒体损伤"恶性循环假说,从宏观和微观两个层面上构建了中西医研究脓毒性心肌病的重要汇合点."虚气流滞"病机和"炎症-线粒体损伤"的恶性循环假说的契合打开了脓毒性心肌病研究的新视角.
Pathogenesis of"Deficient-Qi Induced Stagnation"in Sepsis-Induced Cardiomyopathy and the Vicious Cycle Hypothesis of"Inflammation-Mitochondrial Damage"
Sepsis-induced cardiomyopathy is an acute reversible cardiac dysfunction caused by sepsis,with a complex pathological mechanism.Under the influence of Academician Wang Yongyan's innovative theory of"defi-cient-qi induced stagnation"pathogenesis,this article analyzes the pathogenesis of"deficient-qi induced stagna-tion"in sepsis-induced cardiomyopathy.Based on modern research results,the vicious cycle hypothesis of"inflam-mation-mitochondrial damage"in sepsis-induced cardiomyopathy is summarized,and an important convergence point for the study of sepsis-induced cardiomyopathy in Chinese and western medicine is constructed from both macro and micro levels.The agreement between the pathogenesis of"deficient-qi induced stagnation"and the vi-cious cycle hypothesis of"inflammation-mitochondrial damage"has opened up a new perspective in the study of sepsis-induced cardiomyopathy.

Sepsis-induced cardiomyopathyDeficient-qi induced stagnationInflammationMitochondriaPathogenesis

黄坡、方晓磊、刘清泉

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北京中医药大学东方医院,北京 100078

首都医科大学附属北京中医医院,北京 100010

脓毒性心肌病 虚气流滞 炎症 线粒体 病机

国家自然科学基金项目睿E(睿意)急诊医学科研专项基金项目

822050702021-睿E-010

2024

中国中医急症
中华中医药学会

中国中医急症

CSTPCD
影响因子:1.144
ISSN:1004-745X
年,卷(期):2024.33(7)
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