首页|加味大黄牡丹汤联合中药灌肠治疗急性胰腺炎的临床观察

加味大黄牡丹汤联合中药灌肠治疗急性胰腺炎的临床观察

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目的 观察加味大黄牡丹汤联合中药灌肠治疗急性胰腺炎(AP)的临床疗效.方法 选取非胆源性AP患者60例,由计算机随机分配成对照组与观察组.对照组给予西医基础治疗加开塞露保留灌肠,治疗组在对照组基础上加用大黄牡丹汤口服,灌肠用药为中药方剂(大承气合六君子汤),两组患者治疗时间均为5 d.比较两组患者治疗前后血淀粉酶、白细胞计数、C反应蛋白、改良CT严重指数(MCTSI)评分、中医证候积分、住院天数等,并比较两组患者临床疗效.结果 治疗后,两组血淀粉酶、白细胞计数、C反应蛋白、MCTSI评分、中医证候积分均下降(P<0.05),治疗组各项指标均明显优于对照组(P<0.05);治疗组痊愈率30.00%、总有效率93.33%,明显高于对照组的13.33%、70.00%(P<0.05).结论 加味大黄牡丹汤联合中药灌肠可在短期内明显降低AP患者血淀粉酶、白细胞计数、C反应蛋白、MCTSI评分、中医证候积分,减少住院天数,显著提升AP的临床疗效.
Clinical Observation on the Treatment of Acute Pancreatitis with Modified Dahuang Mudan Decoction Combined with Chinese Medicine Enema
Objective:To observe the clinical efficacy of Modified Dahuang Mudan Decoction combined with traditional Chinese medicine enema in the treatment of acute pancreatitis.Methods:60 patients with non biliary acute pancreatitis who were randomly assigned to a control group and an observation group by computer,with 30 patients in each group.The control group received basic treatment with western medicine and glycerine enema,while the treatment group received oral administration of Dahuang Mudan Decoction on the basis of the control group.The enema medication was a traditional Chinese medicine formula(Dachengqi and Liujunzi Decoction),and the treatment time for both groups of patients was 5 days.The changes in serum amylase,white blood cell count,C-reactive protein,modified CT severity index score,traditional Chinese medicine syndrome score,and length of hospital stay between two groups before and after treatment were compared,and the clinical efficacies of the two groups were evaluated.Results:There was no significant difference in the above observation indicators between the two groups of patients before treatment(P>0.05).The decrease in the above observation indicators in the treat-ment group was dominantly better than control group after treatment(P<0.05);the total effective rate of treatment group(93.33%)was apparently better than the control group(70.00%)(P<0.05),and the recovery rate of the treat-ment group(30.00%)was better than the control group(13.33%).Conclusion:The combination of Modified Da-huang Mudan Decoction and traditional Chinese medicine enema can significantly reduce blood amylase,white blood cell count,C-reactive protein,MCTSI score,and traditional Chinese medicine syndrome score in patients with acute pancreatitis in the short term,reduce hospitalization days,and remarkably increase the clinical efficacy of acute pancreatitis,which is worth promoting in clinical practice.

Acute pancreatitisDahuang Mudan DecoctionChinese medicine enemaDachengqi DecoctionLiu-junzi DecoctionClinical efficacy

郭思远、颜桂林、郭耀荣、白娜、陶杨

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广州中医药大学,广东 广州 510405

广州中医药大学第一附属医院重庆医院,重庆 400700

重庆医科大学,重庆 400016

急性胰腺炎 大黄牡丹汤 中药灌肠 大承气汤 六君子汤 临床疗效

重庆市中医药重点学科建设项目重庆市卫生健康委医学科研项目

2022WSJK130

2024

中国中医急症
中华中医药学会

中国中医急症

CSTPCD
影响因子:1.144
ISSN:1004-745X
年,卷(期):2024.33(7)
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