Effect of Modified Poge Jiuxin Decoction on Biomarkers of Ventricular Arrhythmia and Recent Adverse Cardiovascular Events in Patients with Heart Failure
Objective:To evaluate the effect of Modified Poge Jiuxin Decoction on biomarkers of ventricular ar-rhythmia and short-term adverse cardiovascular events in patients with heart failure.Methods:88 patients with heart failure complicated with ventricular arrhythmia were randomly divided into the control group and observation group,44 cases for each group.In the control group,anti-heart failure treatment was performed,and metoprolol sustained-release tablets and amiodarone hydrochloride capsules were orally administered.In the observation group,on the basis of the treatment in the control group,Poge Jiuxin Decoction was orally administered.The LVEF,SV,LVESD,QTc,TP-Tec,SDNN,SDANN and Pnn50％were compared before and after treatment;NT-proBNP,GDF-15,sST-2 and GAL-3 levels were measured;short-term adverse cardiovascular events were record-ed;Yang Qi deficiency and blood stasis syndrome scores were performed before and after treatment;and cardiac function efficacy and ventricular arrhythmia efficacy were compared.Results:After treatment,the total effective rates of cardiac function and ventricular arrhythmia in the observation group were higher than those in the control group(P＜0.05).After treatment,LVEF and SV increased and LVESD decreased in both groups(P＜0.05),espe-cially in the observation group(P＜0.05).After treatment,NT-proBNP,GAL-3,GDF-15 and sST2 levels de-creased in both groups(P＜0.05),and were lower in the observation group than in the control group(P＜0.05).Af-ter treatment,the main symptom score and the total score of Yang Qi deficiency and blood stasis syndrome de-creased in the two groups(P＜0.05),and the observation group was lower than the control group(P＜0.05).After treatment,QTc and TP-Tec decreased,SDNN,SDANN and Pnn50％increased in both groups(P＜0.05),and were significant in the observation group(P＜0.05).The cumulative incidence of recent adverse cardiovascular events in the observation group was lower than that in the control group(P＜0.05).Conclusion:Modified Poge Jiuxin De-coction combined with conventional western medicine treatment of heart failure with ventricular arrhythmia,inhibit ventricular remodeling,improve cardiac function,reduce the occurrence of adverse cardiovascular events,clinical efficacy is better than western medicine alone.
Heart failureVentricular arrhythmiaSyndrome of Yang Qi deficiency and blood stasisPoge Jiux-in DecoctionVentricular remodelingAdverse cardiovascular events
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