Clinical Efficacy Observation on Electropuncture Combined with Dachengqi Decoction in Treating Gastro-intestinal Dysfunction of Sepsis(Syndrome of Stagnant and Jamming Dampness-heat)
Objective:To observe the clinical efficacy of synergistic treatment of patients with gastrointestinal dysfunction of sepsis(syndrome of stagnant and jamming dampness-heat)by combining acupuncture and medi-cine.Methods:64 patients were randomly and equally divided into two groups.The control group was treated with conventional western medicine,and the treatment group was given Dachengqi Decoction orally and electroacu-puncture(Shangwan,Zhongwan,bilateral Tianshu,and bilateral Zusanli acupoints).After 7 days of treatment,the two groups were compared in terms of efficacy,changes in intestinal mucosal barrier function indexes,inflammato-ry response level,gastrointestinal symptom score,acute physiological and chronic health score(APACHE Ⅱ),and sequential organ failure estimation score(SOFA).Results:After 7 days of treatment,the total clinical effective-ness rate of the treatment group was 93.75％,which was significantly higher than 75.00％of the control group,and the difference was statistically significant(P＜0.05).After treatment,the APACHE Ⅱ score,SOFA score and gastro-intestinal symptom score of the two groups were significantly lower than those before treatment,and the difference was statistically significant(P＜0.05).The treatment group was significantly lower than the control group,and the difference was statistically significant(P＜0.05).After treatment,the levels of C-reactive protein(CRP),white blood cells(WBC),interleukin-6(IL-6)and lactate(Lac)in the two groups were significantly lower than those be-fore treatment(P＜0.05),and the inflammatory index levels in the treatment group were significantly lower than those in the control group(P＜0.05).After treatment,the levels of intestinal fatty acid binding protein(IFABP)and diamine oxidase(DAO)decreased compared with those before treatment,and the levels of citrulline(Cit)in-creased compared with those before treatment,but there was no statistical significance(P＞0.05).The intestinal barrier function indexes in the treatment group were improved after treatment,and the difference was statistically significant(P＜0.05).The improvement in the treatment group was more significant,and the difference was statisti-cally significant(P＜0.05).Conclusion:On the basis of conventional western medical treatment,the combination of acupuncture and medicine can synergistically promote the recovery of gastrointestinal dynamics in patients with sepsis gastrointestinal dysfunction(syndrome of stagnant and jamming dampness-heat),which has a protective ef-fect on the intestinal barrier function;at the same time,it can reduce inflammatory reactions of the body,improve the level of serum Cit,IFABP and DAO,reduce the critical degree of the patients'condition,and avoid the vicious circle.
SepsisGastrointestinal dysfunctionCombination of acupuncture and medicineSerum markers of intestinal dysfunctionIntestinal mucosal barrier function
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