Clinical Observation of Modified Buyang Huanwu Decoction on Patients with Coronary Heart Disease Angina Pectoris for Syndrome of Blood Stasis Due to Qi Deficiency
Objective:To observe the effect of Modified Buyang Huanwu Decoction on heart function,inflamma-tory factors,and stress indicators in patients with coronary heart disease angina pectoris(syndrome of blood stasis due to qi deficiency).Methods:160 patients with coronary heart disease angina pectoris(syndrome of blood sta-sis due to qi deficiency)were divided into the control group and observation group by random number table meth-od.The control group was treated with conventional treatment while the observation group was given Modified Buy-ang Huanwu Decoction on the basis of the control group.The clinical efficacy,TCM syndrome scores,heart func-tion laboratory and ultrasound indicators[N-terminal pro brain natriuretic peptide(NT-proBNP),cardiac Tropo-nin Ⅰ(cTnⅠ),creatine kinase isozyme(CK-MB),left ventricular end diastolic diameter(LVEDD),left ventricular end diastolic volume(LVEDV),left ventricular ejection fraction(LVEF),cardiac index(CI)];inflammatory indexes[high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),ratio of monocyte to high-density lipoprotein cholesterol(MHR)];stress indicators[superoxide dismutase(SOD),malondi-aldehyde(MDA),endothelin-1(ET-1),cortisol(COR),cystatin C(Cys C)]were compared between the two groups.Results:The TCM syndrome scores of the observation group were significantly lower than those of the con-trol group(P＜0.05);the NT-proBNP,cTnⅠ,CK-MB,LVEDD,LVEDV,hs-CRP,TNF-α,IL-6,MHR,MDA,ET-1,COR and Cys C of the observation group were lower than those of the control group(P＜0.05);after treatment,the LVEF,CI,and SOD of the observation group showed higher levels than the control group(P＜0.05);the total effec-tive rate of the observation group was significantly higher than the control group(P＜0.05).Conclusion:Modified-Buyang Huanwu Decoction can significantly improve the heart function with angina pectoris of coronary artery dis-ease(syndrome of blood stasis due to qi deficiency),reduce inflammation and stress reaction.further improve the TCM syndrome,and improve clinical efficacy.
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