Prospective Clinical Controlled Study of Jiedu Qinghuo Mixture for Acute Bacterial Pharyngitis(Syndrome of Heat Exuberance in Lung and Stomach)
Objective:To observe the clinical efficacy of Jiedu Qinghuo Mixture in the treatment of acute bacte-rial pharyngitis(syndrome of heat exuberance in lung and stomach)and its effect on patients'serum inflammation indicators.Methods:One hundred patients were divided into a control group and an observation group,50 pa-tients each,according to the block randomization principle.The control group received antibiotic treatment,while the observation group was additionally treated with Jiedu Qinghuo Mixture.The clinical efficacy after intervention and changes in symptom scores and inflammation indicators before and after intervention were compared.Results:The cure rate in the control group was 68.00％,which was lower than 90.00％in the observation group(P＜0.05).After treatment,the Visual Analogue Scale(VAS)score in the observation group was significantly lower than that in the control group,while the Brief Pain Inventory(BPI)score was significantly higher(P＜0.01).After interven-tion,the observation group showed a significant decrease in scores for main symptoms such as sore throat,thirst,redness in the throat,and fever compared with the control group(P＜0.01);furthermore,serum levels of IL-1β,IL-6,and CRP in the observation group were also significantly lower than in the control group(P＜0.01).During the intervention,major adverse reactions in all patients included nausea,vomiting,loss of appetite,abdominal pain,di-arrhea,and rash,with no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion:Jiedu Qinghuo Mixture demonstrates good clinical efficacy in the treatment of acute bacterial pharyngitis(syndrome of heat exuberance in lung and stomach),which is capable of alleviating symptoms such as sore throat,excessive thirst,redness in the throat,and fever.Its mechanism of action is related to reducing serum inflammatory factor levels and suppressing inflammatory responses.
Acute bacterial pharyngitisSyndrome of heat exuberance in lung and stomachJiedu Qinghuo Mix-tureInflammation levelsClinical study
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