Clinical Efficacy Observation of Kanggan Mixture in Treating Patients with Acute High Fever Phase of Influenza(Syndrome of Heat-toxin Attacking Lung)
Objective:To observe the clinical efficacy of Kanggan Mixture in treating patients with influenza during the acute high fever phase(syndrome of heat-toxin attacking lung).Methods:A total of 204 patients were divided into an observation group and a control group of 102 cases each using the random number table method.The control group received oseltamivir treatment,while the observation group received a combination of oseltamivir and Kanggan Mixture.The recovery rates of main influenza symptoms,improvement of body temperature,viral nu-cleic acid negative conversion rate,and laboratory indicators were compared between the two groups.Results:The recovery rate of main influenza symptoms in the observation group on days 5 to 7 was higher than that in the con-trol group(P＜0.05).The time for recovery of five individual influenza symptoms including fatigue,cough,thirst,headache,and sore throat was shorter in the observation group compared with the control group(P＜0.01).The me-dian time to defervescence in the observation group was 7 hours shorter than in the control group,with a statistical-ly significant difference(P＜0.05).The proportion of patients who had a fever reduction at 24 and 36 hours was significantly higher in the observation group than in the control group(P＜0.05).After treatment,the increase in lymphocyte percentage(LY％)in the observation group was more significant than in the control group(P＜0.05);after treatment,the decrease in C-reactive protein(CRP)and interleukin-6(IL-6)levels in the observation group was more significant than in the control group(P＜0.05).After treatment,the level of alanine aminotransferase(ALT)elevation in the observation group was lower than in the control group(P＜0.05);after treatment,the im-provement in creatine kinase(CK)and CK-MB in the observation group was significantly better than in the con-trol group(P＜0.05).During the course of treatment,at the 3 day and 5 day time points,the viral nucleic acid neg-ative conversion rate was significantly better in the observation group compared to the control group(P＜0.05),in-dicating a stronger antiviral effect of Kanggan Mixture against influenza virus.Conclusion:The combination thera-py with Kanggan Mixture in treating patients with influenza during the acute high fever phase(syndrome of heat-toxin attacking lung)demonstrates significant efficacy,which is superior to the use of oseltamivir alone.The com-bined use can shorten the duration of influenza and fever,adjust serum inflammatory markers,improve myocardial enzymes,reduce the risk of viral myocarditis,and has good safety.
InfluenzaAcute High Fever PhaseKanggan MixtureSyndrome of heat-toxin attacking lungClini-cal efficacy
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