Efficacy Observation on Qingre Chushi Decoction in Treating Acute Eczema(Syndrome of Accumulated Dampness-heat)
Objective:To observe the efficacy of Qingre Chushi Decoction in treating Acute eczema(syndrome of accumulated dampness-heat)and to preliminarily analysis the related mechanism.Methods:Totally 96 pa-tients with acute eczema were selected and divided into an observation group and a control group according to ran-dom number table method,with 48 patients in each group.The control group were treated with 3％boric acid lo-tion for external use and cloloratadine capsules orally,while the observation group were treated with traditional Chi-nese medicine Qingre Chushi Decoction orally on this basis.The treatment courses for both groups were 2 weeks.The symptom scores(eczema area,itching degree,eczema morphology,rash color),eczema area and severity index(EASI score),itching visual analogue scale(VAS)score before and after treatment,and the content of peripheral blood eosinophils(EOS),interleukin-4(IL-4),immunoglobulin E(IgE),and the relative expression of interleukin-22(IL-22)mRNA and aromatic hydrocarbon receptor(AhR)mRNA,and the total effective rate of the two groups were compared.Results:After treatment,the symptom score,EASI score,and itching VAS of the observation group were lower than those of the control group(P＜0.05).The levels of EOS,IL-4,IgE in peripheral blood,as well as the relative expression of IL-22 mRNA and AhR mRNA were lower than those of the con-trol group(P＜0.05).The total effective rate of the observation group was higher than that of the control group(P＜0.05).Conclusion:Qingre Chushi Decoction can effectively alleviate the condition,alleviate clinical symptoms,reduce the levels of EOS,IL-4,and IgE in the peripheral blood,and has a significant effect on the treatment of acute eczema with syndrome of accumulated dampness-heat.Its mecha-nism may be related to the reduction of IL-22 mRNA and AhR mRNA levels.
Acute eczemaAccumulated dampness-heatTraditional Chinese medicineQingre Chushi DecoctionIL-22Aromatic hy-drocarbon receptors
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