Effects of Acupoint Embedding Needle Combined with Pentoxifylline on Coagulation,Immune Function and Inner Ear Microcirculation in Patients with Sudden Deafness
Objective:To explore the effects of acupoint embedding needle combined with pentoxifylline on co-agulation,immune function,and inner ear microcirculation in patients with sudden deafness.Methods:Totally 100 patients with sudden deafness were selected and randomly divided into a control group and a study group us-ing random number table method,with 50 cases in each group.The control group was treated with conventional western medicine,while the study group was treated with acupoint embedding needle combined with pentoxifylline on the basis of the control group.The clinical efficacy of the two groups was compared,and the disappearance time of dizziness,tinnitus,and ear tightness were recorded.The degree of hearing loss,diameter of the internal au-ditory artery and anterior inferior cerebellar artery in the inner ear canal were measured,and immunoglobulin G(IgG),T lymphocyte subsets CD4+,CD8+,thrombin time,fibrinogen,prothrombin time,endothelin-1(ET-1),cys-tatin C(CysC),and soluble vascular cell adhesion molecule-1(sVCAM-1)levels were measured.Results:After treatment,the total effective rate of the study group was higher than that of the control group(P＜0.05);the disap-pearance time of dizziness,tinnitus,and ear tightness in the study group were shorter than those in the control group(P＜0.05);the degree of hearing loss in the study group was lower than that in the control group(P＜0.05);the diameter of the auditory artery and anterior inferior cerebellar artery in the study group was larger than that in the control group(P＜0.05);the average levels of CD8+,ET-1,CysC,sVCAM-1,and fibrinogen in the study group were lower than those in the control group(P＜0.05),while the levels of IgG and CD4+in the study group were higher than those in the control group(P＜0.05);the thrombin time and prothrombin time in the study group were longer than those in the control group(P＜0.05).Conclusion:The combination of acupoint embedding needle and pentoxifylline can effectively improve vascular endothelial function,immune function,and coagulation function in the treatment of sudden deafness,reduce hearing damage,improve microcirculation in the ear,and enhance clini-cal efficacy.
Sudden deafnessAcupoint embedding needlePentoxifyllineVascular endothelial functionIm-mune functionMicrocirculation in the ear
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