Study on the Molecular Mechanism of Qiyin Sanliangsan in the Treatment of Targeted Drug-related Rash
Objective:To explore the molecular mechanism of the core drug composition of Qiyin Sanliangsan,and to construct the visual network relationship of"Qiyin Sanliangsan-active ingredients of drugs-key action tar-gets-corresponding targets of targeted drug-related rash"through network pharmacology analysis.Methods:Based on TCMSP and BATMAN-TCM,the active ingredients and effective targets of Qiyin Sanliangsan core drugs were screened,and the bioactive ingredients and effective targets in the compound were extracted by fishing for the core compound target.The corresponding targets of targeted drug-related rash were obtained by ADReCS-Tar-get.Protein-protein interaction(PPI)was constructed by STRING database,and Cytoscape 3.8.2 software was used to analyze the network topology and screen the key targets.DAVID v6.8 database was used to enrich the key tar-gets and predict the possible molecular biological mechanism of the core drug composition in Qiyin Sanliangsan.Results:Totally 118 kinds of effective bioactive ingredients in the core prescription were retrieved,including 328 potential predicted targets,214 corresponding targets of targeted drug-related rash,and 86 common targets of ac-tive ingredients in the core prescription targeted drug-related rash were obtained by matching the two,including 8 key targets;the compound had important effects on 210 biological processes and 81 signaling pathways.Conclu-sion:The potential mechanism of Qiyin Sanliangsan in the treatment of targeted drug-related rash may be through signal transduction such as PI3K-Akt signaling pathway and cytokine-cytokine receptor interaction,regu-lating the proliferation and differentiation of stratum corneum cells,and repairing skin lesions caused by EGFR-TKI,which provides a reference direction for future drug research and development and related clinical research.
Targeted drug-related rashQiyin SanliangsanNetwork pharmacologyTraditional Chinese medi-cine