Clinical Study of Zhongfeng Decoction Treatment for Acute Ischemic Stroke Based on Real-world Study
Objective:To explore the clinical efficacy of Zhongfeng Decoction in the treatment of acute isch-emic stroke based on real-world clinical data.Methods:A retrospective study method was employed,including 395 hospitalized patients with acute ischemic stroke.Patients were divided into a treatment group that received Zhongfeng Decoction and a control group that did not receive the decoction.The changes in the National Institutes of Health Stroke Scale(NIHSS)scores before and after treatment were compared between the two groups to evalu-ate the clinical efficacy of Zhongfeng Decoction in treating acute ischemic stroke.Results:Baseline characteris-tics were balanced and comparable between the two groups(P＞0.05).After treatment,the NIHSS scores in the treatment group significantly decreased compared to before treatment(P＜0.05).The effective rate in the treat-ment group was significantly higher than in the control group,with statistically significant differences(P＜0.05).In patients with mild,moderate,and severe neurological deficits,the effective rate in the treatment group was signifi-cantly higher than in the control group,with statistically significant differences(all P＜0.05).Subgroup analysis showed that in male patients,the effective rate in the treatment group(47.00％)was significantly higher than in the control group(23.29％),with statistically significant differences(P＜0.05);however,there was no statistically significant difference in the distribution of effective rates between the two groups in female patients(P＞0.05).In patients with ischemic stroke and comorbid hypertension,the effective rate in the treatment group(49.47％)was significantly higher than in the control group(23.19％),with statistically significant differences(P＜0.05);however,there was no statistically significant difference in the distribution of effective rates between the two groups in pa-tients without comorbid hypertension(P＞0.05).In patients with ischemic stroke and comorbid diabetes,the effec-tive rate in the treatment group(39.74％)was significantly higher than in the control group(15.38％),with statisti-cally significant differences(P＜0.05);similarly,in patients without comorbid diabetes,the effective rate in the treatment group(50.00％)was significantly higher than in the control group(28.40％),with statistically significant differences(P＜0.05).Conclusion:In real-world clinical practice,applying Zhongfeng Decoction effectively im-proves neurological deficits in patients with acute ischemic stroke and enhances clinical efficacy.
Ischemic strokeReal-world studyZhongfeng DecoctionNational Institutes of Health Stroke Scale
NETL
NSTL
万方数据
