基于真实世界研究中风合剂治疗急性缺血性脑卒中的临床研究
Clinical Study of Zhongfeng Decoction Treatment for Acute Ischemic Stroke Based on Real-world Study
古联 1宋潇宵 2刘声莹 3王洪海 2王伟涛2
作者信息
- 1. 广西中医药大学第一附属医院,广西 南宁 530023
- 2. 广西中医药大学,广西 南宁 530001
- 3. 广西医科大学,广西南宁 530021
- 折叠
摘要
目的 基于真实世界临床数据观察中风合剂治疗急性缺血性脑卒中的临床疗效.方法 采用回顾性研究方法,纳入急性缺血性脑卒中住院患者395例.根据患者是否服用中风合剂治疗,分为服用中风合剂的治疗组和未服用中风合剂的对照组,比较两组患者治疗前后美国国立卫生研究院卒中量表(NIHSS)评分变化,评估中风合剂治疗急性缺血性脑卒中的临床疗效.结果 两组患者基线均衡可比(P＞0.05).治疗组治疗后NIHSS评分较治疗前下降(P＜0.05).治疗组有效率显著高于对照组,差异具有统计学意义(P＜0.05).在轻度、中度、重度神经功能缺损患者中,服用中风合剂的治疗组有效率均显著高于未服用中风合剂的对照组,差异具有统计学意义(均P＜0.05).亚组分析,男性患者中,治疗组有效率为47.00％,显著高于对照组的23.29％,差异有统计学意义(P＜0.05);但是在女性患者中,有效率在两组之间的分布差异无统计学意义(P＞0.05).在合并高血压的缺血性脑卒中患者中,治疗组有效率(49.47％)显著高于对照组(23.19％),差异有统计学意义(P＜0.05);在无合并高血压病患者中,治疗组与对照组有效率分布差异无统计学意义(P＞0.05).在合并糖尿病的缺血性脑卒中患者中,治疗组有效率(39.74％)显著高于对照组(15.38％),差异有统计学意义(P＜0.05);无合并糖尿病的患者中,治疗组有效率(50.00％)亦显著高于对照组(28.40％),差异也有统计学意义(P＜0.05).结论 真实世界临床实践中服用中风合剂能够有效改善急性缺血性脑卒中患者的神经功能缺损情况,提高临床疗效.
Abstract
Objective:To explore the clinical efficacy of Zhongfeng Decoction in the treatment of acute isch-emic stroke based on real-world clinical data.Methods:A retrospective study method was employed,including 395 hospitalized patients with acute ischemic stroke.Patients were divided into a treatment group that received Zhongfeng Decoction and a control group that did not receive the decoction.The changes in the National Institutes of Health Stroke Scale(NIHSS)scores before and after treatment were compared between the two groups to evalu-ate the clinical efficacy of Zhongfeng Decoction in treating acute ischemic stroke.Results:Baseline characteris-tics were balanced and comparable between the two groups(P＞0.05).After treatment,the NIHSS scores in the treatment group significantly decreased compared to before treatment(P＜0.05).The effective rate in the treat-ment group was significantly higher than in the control group,with statistically significant differences(P＜0.05).In patients with mild,moderate,and severe neurological deficits,the effective rate in the treatment group was signifi-cantly higher than in the control group,with statistically significant differences(all P＜0.05).Subgroup analysis showed that in male patients,the effective rate in the treatment group(47.00％)was significantly higher than in the control group(23.29％),with statistically significant differences(P＜0.05);however,there was no statistically significant difference in the distribution of effective rates between the two groups in female patients(P＞0.05).In patients with ischemic stroke and comorbid hypertension,the effective rate in the treatment group(49.47％)was significantly higher than in the control group(23.19％),with statistically significant differences(P＜0.05);however,there was no statistically significant difference in the distribution of effective rates between the two groups in pa-tients without comorbid hypertension(P＞0.05).In patients with ischemic stroke and comorbid diabetes,the effec-tive rate in the treatment group(39.74％)was significantly higher than in the control group(15.38％),with statisti-cally significant differences(P＜0.05);similarly,in patients without comorbid diabetes,the effective rate in the treatment group(50.00％)was significantly higher than in the control group(28.40％),with statistically significant differences(P＜0.05).Conclusion:In real-world clinical practice,applying Zhongfeng Decoction effectively im-proves neurological deficits in patients with acute ischemic stroke and enhances clinical efficacy.
关键词
缺血性脑卒中/真实世界研究/中风合剂/美国国立卫生研究院卒中量表Key words
Ischemic stroke/Real-world study/Zhongfeng Decoction/National Institutes of Health Stroke Scale引用本文复制引用
出版年
2024
NETL
NSTL
万方数据