A Study on the Distribution Characteristics of Traditional Chinese Medicine Syndromes in Patients with Acute Coronary Syndrome of Different Lipid ApoE Genotypes
Objective:To observe the traditional Chinese medicine(TCM)syndrome characteristics of patients with different ApoE genotypes of acute coronary syndrome(ACS),focusing on the TCM syndrome characteristics of ApoE4 genotype ACS patients.Methods:Information on TCM syndrome and ApoE genotype of 249 ACS patients was collected,and the TCM syndrome characteristics and differences of ACS patients with different ApoE geno-types were analyzed.Results:A total of 32 cases with the ApoE2 genotype,175 cases with the ApoE3 genotype,and 42 cases with the ApoE4 genotype were included.The top three of syndrome elements and syndrome types in each group:1)ApoE2 group:syndrome elements-blood stasis 24 cases,qi deficiency 17 cases,phlegm turbidity 15 cases;syndrome types-interblocking phlegm and blood stasis 5 cases,qi deficiency with phlegm turbidity 5 cases,qi deficiency with blood stasis 3 cases.2)ApoE3 group:syndrome elements-qi deficiency 114 cases,blood stasis 108 cases,phlegm turbidity 61 cases;patterns-qi deficiency with blood stasis 38 cases,interblocking phlegm and blood stasis 17 cases,deficiency in both qi and yin 14 cases.3)ApoE4 group:syndrome elements-qi deficiency 30 cases,phlegm turbidity 24 cases,blood stasis 20 cases;syndrome types-qi deficiency with blood stasis and phlegm turbidity 4 cases,qi deficiency with blood stasis 3 cases,deficiency in both qi and yin 3 cases.Conclusion:The ApoE3 genotype is the most common among lipid gene types.The ApoE2 genotype is more like-ly to present with the pattern of interblocking phlegm and blood stasis;the ApoE3 genotype is more likely to pres-ent with the pattern of qi deficiency with blood stasis;and the ApoE4 genotype is more likely to present with the pattern of qi deficiency with blood stasis and phlegm turbidity.In the pathogenic factor scoring,qi deficiency,blood stasis,phlegm turbidity,and heat accumulation are the highest.TCM pathogenic factors often include phlegm turbidity and heat accumulation,and the patterns are predominantly mixed,with a high incidence of phlegm turbidity.
Acute coronary syndromeLipid ApoE genotypeTraditional Chinese medicine syndrome elementsTraditional Chinese medicine syndrome types
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