Effect of Modified Changpu Yujin Decoction on Liver Function,Inflammatory Factors and Serum Endotoxin in Patients with HBV-related Acute-on-chronic Liver Failure
Objective:To evaluate the clinical efficacy of Modified Changpu Yujin Decoction in the treatment of HBV-related acute-on-chronic liver failure(HBV-ACLF)with toxic heat accumulation syndrome and its influ-ence on inflammatory factors and serum endotoxin(ET).Methods:A total of 64 patients with HBV-ACLF were randomly divided into control group(n=32)and observation group(n=32).In the control group,comprehensive western medicine treatment measures were given;in the observation group,Modified Changpu Yujin Decoction was orally administered on the basis of treatment in the control group.The course was 4 weeks.Serum total bilirubin(TBil),alanine aminotransferase(ALT),aspartate aminotransferase(AST),albumin(Alb),prothrombin activity(PTA),fibrinogen(FIB),prothrombin time(PT),international normalized ratio(INR)and platelet count(PLT)were measured before and after treatment;chronic liver failure alliance-chronic plus acute liver failure prognosis(CLIF-CACLF)score and toxic heat accumulation syndrome score were compared before and after treatment;in-terleukin(IL)-2,IL-17,interferon(IFN)-y,tumor necrosis factor-α(TNF-α)and ET levels were measured be-fore and after treatment.Results:After treatment,the TBil,ALT,AST,PT and INR levels decreased,Alb,PTA,FIB and PLT levels increased in the two groups(P＜0.05),and after treatment,TBil,ALT,AST,PT and INR in the observation group were lower than those in the control group(P＜0.05),Alb,PTA,FIB and PLT levels were higher than those in the control group(P＜0.05);CLIF-CACLF score and ET levels decreased(P＜0.05)in the two groups after treatment,and IL-2,IL-17,IFN-γ and TNF-α levels decreased(P＜0.05)in the two groups after treatment,and they were lower in the observation group than in the control group after treatment(P＜0.05);major symptom score and total score decreased(P＜0.05),and after treatment,the observation group was lower than those in the control group(P＜0.05);after treatment,the total effective rate of clinical efficacy was 90.62％in the observation group and 68.75％in the control group,and the observation group was higher than the control group(P＜0.05).Conclusion:Modified Changpu Yujin Decoction can inhibit inflammatory factors and endotoxemia,re-duce the degree of injury,promote the recovery of liver function,improve coagulopathy and reduce clinical symp-toms in patients with HBV-ACLF toxic heat accumulation syndrome.The clinical efficacy is superior to western medicine alone,which is worthy of further study and use.
NETL
NSTL
万方数据
