A Randomized Controlled Clinical Study of Integrated Traditional Chinese and Western Medicine Using Modified Liangge Powder for Treating Sepsis(Syndrome of Blazing Heat-toxin)
Objective:To observe the clinical efficacy of integrated traditional Chinese and western medicine us-ing Modified Liangge Powder for treating sepsis(syndrome of blazing heat-toxin).Methods:Patients were ran-domly divided into a treatment group(conventional western medicine treatment plus modified Liangge powder granules)and a control group(conventional western medicine treatment).Both groups received a 14 day course of treatment.The clinical efficacy was observed,and the cumulative survival rate on day 28,Sequential Organ Failure Assessment(SOFA)scores,Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ)scores,TCM syn-drome scores,complete blood count,C-reactive protein,blood lactate,procalcitonin(PCT),tumor necrosis factor al-pha(TNF-α),interleukin-6(IL-6),interleukin-8(IL-8),and heparin-binding protein(HBP)were compared be-fore and after treatment between the two groups.Results:The cumulative survival rates on day 28 for the treat-ment and control groups were 77.46％and 63.89％,respectively,with the treatment group showing significantly bet-ter survival(P＜0.05).After treatment,the SOFA scores,APACHE Ⅱ scores,and TCM syndrome scores were sig-nificantly lower in the treatment group than in the control group(P＜0.05).The treatment group also showed signif-icantly lower levels of white blood cell count(WBC),neutrophil percentage,TNF-α,IL-6,HBP,and PCT com-pared to the control group(P＜0.05).Conclusion:The integrated treatment using Modified Liangge Powder for sepsis(syndrome of blazing heat-toxin)demonstrates good clinical efficacy.
SepsisModified Liangge PowderSyndrome of blazing heat-toxinIntegrated traditional Chinese and western medicine
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