摘要
目的 观察融合加味凉膈散的中西医结合疗法治疗脓毒症(热毒炽盛证)的临床疗效.方法 将患者随机分为治疗组(西医常规治疗+加味凉膈散颗粒剂)和对照组(西医常规治疗),两组疗程均14 d,观察临床疗效,比较两组第28天生存率以及治疗前后序贯性器官功能衰竭量表(SOFA)评分、急性生理与慢性健康量表(APACHE Ⅱ)评分、中医证候评分、血常规、C反应蛋白(CRP)、血乳酸、降钙素原(PCT)、肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肝素结合蛋白(HBP)的差异.结果 治疗组、对照组的第28天生存率分别为77.46％、63.89％,治疗组明显优于对照组(P＜0.05).治疗后,治疗组SOFA评分、APACHE Ⅱ评分和中医证候评分均低于对照组(P＜0.05),白细胞计数(WBC)、中性粒细胞百分比、TNF-α、IL-6、HBP、PCT明显低于对照组(P＜0.05).结论 融合加味凉膈散的中西医结合治疗脓毒症(热毒炽盛证)具有良好的疗效.
Abstract
Objective:To observe the clinical efficacy of integrated traditional Chinese and western medicine us-ing Modified Liangge Powder for treating sepsis(syndrome of blazing heat-toxin).Methods:Patients were ran-domly divided into a treatment group(conventional western medicine treatment plus modified Liangge powder granules)and a control group(conventional western medicine treatment).Both groups received a 14 day course of treatment.The clinical efficacy was observed,and the cumulative survival rate on day 28,Sequential Organ Failure Assessment(SOFA)scores,Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ)scores,TCM syn-drome scores,complete blood count,C-reactive protein,blood lactate,procalcitonin(PCT),tumor necrosis factor al-pha(TNF-α),interleukin-6(IL-6),interleukin-8(IL-8),and heparin-binding protein(HBP)were compared be-fore and after treatment between the two groups.Results:The cumulative survival rates on day 28 for the treat-ment and control groups were 77.46％and 63.89％,respectively,with the treatment group showing significantly bet-ter survival(P＜0.05).After treatment,the SOFA scores,APACHE Ⅱ scores,and TCM syndrome scores were sig-nificantly lower in the treatment group than in the control group(P＜0.05).The treatment group also showed signif-icantly lower levels of white blood cell count(WBC),neutrophil percentage,TNF-α,IL-6,HBP,and PCT com-pared to the control group(P＜0.05).Conclusion:The integrated treatment using Modified Liangge Powder for sepsis(syndrome of blazing heat-toxin)demonstrates good clinical efficacy.
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