Clinical Observation of Nashen Jiangfei Pingchuan Decoction Combined with Non-invasive Ventilator in the Treatment of COPD Complicated with Respiratory Failure
Objective:To explore the clinical efficacy and incidence of adverse reactions of Nashen Jiangfei Pingchuan Decoction combined with non-invasive ventilator in the treatment of chronic obstructive pulmonary dis-ease(COPD)complicated with respiratory failure(syndrome of turbid phlegm obstructing lung and syndrome of de-ficiency of kidney failing to control respiring qi).Methods:64 patients were randomly divided into two groups of 32 each.The control group received conventional western medical treatment,while the treatment group received ad-ditional treatment with Nashen Jiangfei Pingchuan Decoction on top of the conventional treatment.After 7 days of treatment,the clinical efficacy and the scores for main TCM symptoms were compared between the two groups.Ob-servations were made on arterial blood gas oxygen partial pressure(PO2),carbon dioxide partial pressure(PCO2),oxygenation index(PO2/FiO2),Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ)score,mechanical ventilation time,extubation failure rate,ICU stay duration,and the incidence of adverse reactions such as abdomi-nal distension,poor appetite,and insomnia during the treatment period.Results:The overall effective rate in the treatment group was 93.75％,which was higher than the 81.25％in the control group(P＜0.05).After treatment,the scores for main TCM symptoms,PCO2,and APACHE Ⅱ score decreased significantly,while PO2 and PC2/FiO2 increased significantly in both groups,with the treatment group showing better improvement(P＜0.05).The treat-ment group had shorter mechanical ventilation time,ICU stay duration,and lower extubation failure rate compared to the control group(P＜0.05).During the treatment period,the incidence of adverse reactions such as abdominal distension,poor appetite,and insomnia was 15.62％in the treatment group,which was lower than the 40.62％in the control group(P＜0.05).Conclusion:The combination of Nashen Jiangfei Pingchuan Decoction and non-inva-sive ventilator therapy for COPD complicated with respiratory failure(syndrome of turbid phlegm obstructing lung and syndrome of deficiency of kidney failing to control respiring qi)can effectively improve clinical symptoms and lung oxygenation indicators,shorten the duration of ventilator use and ICU stay,and has high safety,which is wor-thy of clinical promotion and application.
Chronic obstructive pulmonary diseaseTurbid phlegm obstructing lungDeficiency of kidney fail-ing to control respiring qiOxygenation indexClinical observation
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