Meta-analysis and Systematic Review of Xuefu Zhuyu Decoction in the Treatment of Acute Cerebral Infarction
Objective:To systematically evaluate the clinical efficacy and safety of Xuefu Zhuyu Decoction in the treatment of acute cerebral infarction,and to provide evidence-based medical evidence for Xuefu Zhuyu Decoc-tion in the treatment of acute cerebral infarction.Methods:A computerized search was performed for randomized controlled trials(RCTs)on the treatment of acute cerebral infarction with Xuefu Zhuyu Decoction in PubMed,Wan-fang database,China National Knowledge Infrastructure(CNKI),and VIP from the inception of database to March 2024.Cochrane Risk Assessment Scale was used to evaluate the quality of the studies.Data were extracted using RevMan 5.4 software for sensitivity analysis and publication bias analysis,followed by a meta-analysis.Results:A total of 19 RCTs involving 1856 patients were included.Meta-analysis showed that the combined use of Xuefu Zhuyu Decoction with basic western medicine treatment for acute cerebral infarction had a higher overall clinical efficacy rate compared with western medicine alone[OR=4.84,95％CI(3.39,6.91),Z=8.69,P＜0.000 01];im-provement in NIH Stroke Scale(NIHSS)scores[MD=-5.10,95％CI(-6.72,-3.48),Z=6.16,P＜0.000 01];Ac-tivities of Daily Living(ADL)scores[SMD=2.92,95％CI(1.68,4.17),Z=4.60,P＜0.000 01];plasma viscosity[MD=-0.27,95％CI(-0.37,-0.17),Z=5.28,P＜0.000 01];fibrinogen levels[MD=-1.03,95％CI(-1.40,-0.66),Z=5.50,P＜0.000 01];tumor necrosis factor-alpha(TNF-α)levels[MD=-14.47,95％CI(-18.78,-10.16),Z=6.58,P＜0.000 01];and high-sensitivity C-reactive protein(hs-CRP)levels[MD=-1.72,95％CI(-2.18,-1.26),Z=7.28,P＜0.000 01]were significantly better than those treated with western medicine alone,and the differenc-es were all statistically significant.Conclusion:The available evidence suggests that the clinical efficacy of apply-ing Xuefu Zhuyu Decoction combined with western medicine in the treatment of acute cerebral infarction is superi-or to that of applying western medicine therapy alone,but high-quality clinical studies are needed to support this finding.
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