Clinical Efficacy Observation of Shenfu Injection on Brain Injury Protection in Traumatic Cardiac Arrest
Objective:To observe the clinical efficacy of Shenfu Injection in treating brain injury caused by trau-matic cardiac arrest(TCA),and to analyze its effect on brain protection.Methods:A total of 36 patients with re-turn of spontaneous circulation(ROSC)after TCA admitted to the First Affiliated Hospital of Guangxi University of Chinese Medicine from January 2018 to July 2023 were selected as study subjects and were randomly divided into a treatment group and control group,with 18 cases in each group.Both groups received conventional intensive support treatment,while the treatment group was additionally administered Shenfu Injection.The serum levels of S-100β protein and neuron-specific enolase(NSE)were measured and compared between the two groups at 2,24,48,and 72 hours after ROSC using enzyme-linked immunosorbent assay(ELISA)and electrochemiluminescence immunoassay,respectively.Glasgow Coma Scale(GCS)scores were recorded for both groups at 2,24,48,and 72 hours after ROSC,along with the resuscitation success rate and survival rate.Results:The resuscitation success rate of the treatment group was 61.11％,significantly higher than that of the control group(38.89％)(P＜0.05);the survival rate of the treatment group was 33.33％,also significantly higher than that of the control group(5.56％)(P＜0.05).Serum S-100β protein and NSE levels increased significantly in both groups after ROSC(P＜0.05).At 24,48,and 72 hours after ROSC,the S-100β protein and NSE levels in the treatment group gradually de-creased and were significantly lower compared to the control group(P＜0.05).GCS scores increased significantly post-ROSC in both groups(P＜0.05),with the treatment group scoring higher than the control group at 48 and 72 hours post-ROSC(P＜0.05).Conclusion:Administration of Shenfu Injection in addition to conventional resuscita-tion can effectively improve the therapeutic efficacy and prognosis of patients with brain injury due to TCA.
Traumatic cardiac arrestShenfu InjectionS-100βNeuron specific enolaseCerebral injury
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