Effect of Guichen Xuanhua Decoction Combined with t-PA Thrombolytic Therapy on Hemorheology and Neurotrophic Factors in Patients with Ischemic Stroke
Objective:To investigate the effect of Guichen Xuanhua Decoction combined with tissue-type plas-minogen activator(t-PA)thrombolytic therapy on hemorheology and neurotrophic factors in patients with ischemic stroke.Methods:A randomized controlled study was performed on 94 patients with ischemic stroke admitted.Pa-tients were grouped using random number table methods,each with 47 cases.The control group received thrombo-lytic therapy with t-PA,based on this,study group added Guichen Xuanhua Decoction.Treatment in both groups lasted for 14 d.The mean cerebral blood flow velocity(MBF),mean cerebral blood flow(CBF),and dynamic resis-tance(DR)were detected using ultrasonic techniques.Serum levels of neuron-specific enolase(NSE),neutron ther-apy facility(NTF),and nerve growth factor(NGF)were measured using ELISA.The clinical symptoms and clinical efficacy were evaluated using National Institute of Health stroke scale(NIHSS)and modified Rankin scale(MRS).Results:The overall efficacy rate was 95.74％in the study group,which was higher than 80.85％in the control group,with statistical difference(P＜0.05).After treatment,the study group reported larger MBF and CBF values(P＜0.05),smaller DR values(P＜0.05),lower whole blood viscosity,plasma viscosity,and erythrocyte aggregation index(P＜0.05),higher NTF and NGF levels(P＜0.05)and lower NSE level(P＜0.05)than those of control group.The study group scored lower on NIHSS and MRS than control group(P＜0.05).Conclusion:The applica-tion of Guichen Xuanhua Decoction combined with t-PA thrombolytic therapy for patients with ischemic stroke can improve cerebral hemodynamics index,hemorheology index,increase neurotrophic factors and alleviate neuroinflam-mation,and alleviate stroke symptoms.
NETL
NSTL
万方数据
