Evaluation of the Efficacy of Jiedu Sanyu Ointment Combined with Western Medications in Treating Acute Gouty Arthritis(Syndrome of Accumulated Dampness-heat)
Objective:To observe the clinical efficacy of Jiedu Sanyu ointment combined with oral colchicine and etoricoxib in treating acute gouty arthritis(syndrome of accumulated dampness-heat).Methods:A total of 86 patients were randomly divided into an observation group and a control group,each with 43 patients.The control group received oral colchicine tablets and etoricoxib tablets,while the observation group was added with topical ap-plication of Jiedu Sanyu ointment on the basis of the control group.The treatment lasted for 6 consecutive days.Clinical symptoms and signs(TSS)scores,traditional Chinese medicine(TCM)syndrome scores,laboratory indica-tors[white blood cell count(WBC),blood uric acid level(BUA),serum C-reactive protein(CRP),erythrocyte sedi-mentation rate(ESR)],incidence of adverse reactions,and recurrence rates were compared before and after treat-ment.An efficacy assessment was conducted at the end of the treatment period.Results:After treatment,TSS scores and TCM syndrome scores decreased significantly in both groups compared with before treatment(P＜0.05),with a more significant reduction in the observation group(P＜0.05).WBC,BUA,CRP,and ESR levels decreased significantly in both groups after treatment compared with before treatment(P＜0.05);the WBC,CRP,and ESR lev-els were lower in the observation group than those in the control group(P＜0.05),but there was no significant dif-ference in BUA levels between the two groups(P＞0.05).The overall effective rate of the observation group was 94.87％,which was better than the 85.00％in the control group(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups during the study period(P＞0.05).During the 3-month follow-up,there was no significant difference in recurrence rates between the two groups(P＞0.05).Conclu-sion:The combination of topical application of Jiedu Sanyu ointment with oral colchicine and etoricoxib for treat-ing acute gouty arthritis shows definite efficacy,effectively improving symptoms and signs,reducing inflammatory responses,and presenting low recurrence rates and high safety.Compared with monotherapy with western medica-tions,the combination therapy offers greater advantages in improving symptoms,signs,reducing inflammatory factor levels,and alleviating TCM syndromes.
Acute gouty arthritisSyndrome of accumulated dampness-heatJiedu Sanyu ointmentColchicineEtoricoxib
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