Clinical Observation of Qingfei Huatan Zhuyu Decoction in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease(AECOPD)Complicated with Gastrointestinal Dysfunction
Objective:To observe the clinical efficacy of Qingfei Huatan Zhuyu Decoction in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)combined with gastrointestinal dysfunction,and to further explore its underlying mechanism that embodies the co-treatment of lung and intestine.Methods:A to-tal of 98 patients with AECOPD(syndrome of phlegm-heat obstructing lung)and gastrointestinal dysfunction were randomly divided into two groups.The control group received conventional western medicine treatment,while the observation group was additionally treated with Qingfei Huatan Zhuyu Decoction for a course of 2 weeks.The changes in traditional Chinese medicine syndrome scores,Gastrointestinal Symptom Rating Scale(GSRS)scores,mMRC scores,CAT scores,and pulmonary function indicators[1-second forced expiratory volume(FEV1),forced vital capacity(FVC),FEV1/FVC(％),FEV1/predicted value(FEV1/Pred)]were recorded before and after treat-ment.The changes in serum gastrin(GAS),motilin(MTL),diamine oxidase(DAO),and malondialdehyde(MDA)were also monitored.Results:After treatment,the total effective rate of the observation group was 91.49％,which was superior to the control group's 74.47％(P＜0.05).Compared with before treatment,the clinical symptom-relat-ed scores(TCM syndrome scores,GSRS scores,mMRC scores,CAT scores),blood gas(PaCO2),and serum levels of GAS,DAO,and MDA were all reduced after treatment in both groups(P＜0.05).Pulmonary function indicators(FEV1,FVC,FEV1/FVC,FEV1％pred),blood gas(PaO2),and serum MTL levels significantly improved compared with before treatment(P＜0.05).Inter-group comparisons showed that the observation group had better improve-ments in clinical symptom-related scores(TCM syndrome scores,GSRS scores,mMRC scores,CAT scores),blood gas(PaO2,PaCO2),pulmonary function(FEV1,FVC,FEV1％pred),and serum levels of GAS,MTL,DAO,and MDA after treatment(P＜0.05).The pulmonary function indicator FEV1/FVC improved,but there was no statistically sig-nificant difference between the groups(P＞0.05).Conclusion:Modified Qingfei Huatan Zhuyu Decoction can ef-fectively improve the clinical outcomes of AECOPD patients,enhance lung function and oxygenation,regulate gas-trointestinal hormones,promote the repair of intestinal mucosal barriers and recovery of gastrointestinal function,thereby alleviating the condition.
Acute exacerbation of chronic obstructive pulmonary diseaseLung and intestine combined treat-mentSyndrome of phlegm-heat obstructing lungLung functionClinical efficacy
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