Meta-analysis of the Efficacy of Rhubarb Compound Retention Enema in Treating Secondary Gastroin-testinal Dysfunction
Objective:To evaluate the efficacy of rhubarb compound retention enema in treating secondary gas-trointestinal dysfunction.Methods:A computer search was conducted on databases including China National Knowledge Infrastructure(CNKI),Wanfang Medical Network(WF),VIP Information(VIP),China Biology Medi-cine disc(CBM),PubMed,EMbase,and Cochrane Library from inception to June 20,2024.Literature was selected based on inclusion and exclusion criteria,and the quality of included studies was assessed using the Cochrane risk of bias assessment tool.Meta-analysis was performed using Revman5.4.Results:Fifteen randomized controlled tri-als involving 688 patients were included.The results showed that compared with conventional western medicine treatment,rhubarb compound retention enema significantly improved overall clinical efficacy,gastrointestinal dys-function score,APACHE Ⅱ score,TCM syndrome score,recovery time of bowel sounds,first flatus time,first defeca-tion time,relief time of abdominal pain and distension,levels of C-reactive protein(CRP),procalcitonin(PCT),white blood cell count(WBC),tumor necrosis factor-alpha(TNF-α),interleukin-6(IL-6),D-lactate(D-Lac),di-amine oxidase(DAO),intra-abdominal pressure(IAP),serum motilin(MTL),28 day mortality rate,and incidence of multiple organ dysfunction syndrome(MODS).Conclusion:The application of rhubarb compound retention ene-ma can effectively improve the overall clinical efficacy and has good clinical outcomes in treating secondary gastro-intestinal dysfunction.
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