目的 检索近10年中医药治疗癫痫的临床随机对照试验(RCTs)及系统评价/Meta分析研究并对其进行分析与评价,旨在呈现中医药治疗癫痫的证据分布,分析研究的优势和不足,为相关领域提供更多参考依据.方法 检索中国知网、中文科技期刊数据库、万方数据库、中国生物医学数据库、PubMed、Web of Science、Embase、Cochrane Library 8个中英文数据库,纳入近十年中医药治疗癫痫的RCT研究及系统评价/Meta分析,以图文结合的形式展示该领域的证据分布.此外,采用Cochrane系统评价手册的偏倚风险评估工具(ROB 2.0)评估纳入的RCTs研究的方法学质量,采用AMSTAR-2量表进行赋分来评估系统评价及Meta分析的方法学质量.结果 本研究共纳入209篇文献,包括192篇RCTs、17篇系统评价/Meta分析.分析表明近十年总体发文量呈波动上升趋势.中医药治疗癫痫的干预措施种类繁多,多数研究结局指标为疗效、不良反应及临床指标,但对复发率及中医证候评分等指标研究不足.此外,临床RCTs和系统评价/Meta分析的整体方法学质量偏低.结论 尽管多数研究表明中医药治疗癫痫具有优势,但目前仍缺乏高质量的研究证据.这提示该领域需要更多大规模且设计严谨的高质量研究为中医药治疗癫痫提供更多可信且有效的证据.
Evidence Mapping of Clinical Research on Traditional Chinese Medicine Treatment for Epilepsy in Recent Ten Years
Objective:To search for clinical randomized controlled trials(RCTs)and systematic reviews/Meta-analyses on traditional Chinese medicine(TCM)treatment for epilepsy over the past decade,analyze and evaluate them,aiming to present the distribution of evidence for TCM treatment of epilepsy,analyze the strengths and weak-nesses of the research,and provide more reference for the relevant field.Methods:8 databases,including CNKI,VIP,Wanfang,China Biology Medicine disc,PubMed,Web of Science,Embase,and Cochrane Library,were searched for RCTs and systematic reviews/Meta-analyses on TCM treatment for epilepsy published in the past de-cade.The distribution of evidence in this field was presented in a combined form of text and graphics.Further-more,the methodological quality of the included RCTs was evaluated using the Cochrane Risk of Bias Assessment Tool(ROB 2.0),and the methodological quality of systematic reviews and Meta-analyses was assessed using the AMSTAR-2 scale.Results:This study included 209 articles,comprising 192 RCTs and 17 systematic reviews/Me-ta-analyses.Analysis showed that the total number of publications over the past decade has shown a fluctuating upward trend.The interventions of TCM for treating epilepsy are diverse,and most studies focus on outcome indica-tors such as efficacy,adverse reactions,and clinical indicators,but there is insufficient research on recurrence rates and TCM syndrome scores.Additionally,the overall methodological quality of clinical RCTs and systematic reviews/Meta-analyses is relatively low.Conclusion:Although most studies indicate that TCM treatment for epi-lepsy has advantages,there is still a lack of high-quality research evidence.This suggests that the field requires more large-scale and rigorously designed high-quality research to provide more credible and effective evidence for the treatment of epilepsy with TCM.
EpilepsyTraditional Chinese medicineRandomized controlled trialsSystematic reviewsMeta-analysisEvidence mapping
NETL
NSTL
万方数据
