Efficacy Analysis of Safflower Yellow Injection in Patients with Sudden Deafness and Its Impact on Endo-thelial Inflammatory Injury
Objective:To observe the clinical efficacy of saffllower yellow injection in patients with sudden deaf-ness(syndrome of qi stagnation and blood stasis)and its impact on endothelial inflammatory injury.Methods:60 patients were divided into an experimental group and a control group.The control group received hormone therapy,while the experimental group was treated with both hormone therapy and safflower yellow injection.Blood samples were collected before and after treatment to compare the recovery of hearing between the two groups.ELISA was used to detect the levels of interleukin-6(IL-6),intercellular adhesion molecule 1(ICAM-1),and nitric oxide(NO)in serum,and RT-PCR was used to measure the levels of TLR4 mRNA and NF-κB mRNA in serum.Re-sults:The therapeutic effect of the experimental group was significantly better than that of the control group,with statistically significant differences(P＜0.05).After treatment,the levels of IL-6 and ICAM-1 in both groups were significantly lower than before treatment(P＜0.05),and the decrease was more significant in the experimental group compared with the control group(P＜0.05).The content of NO in serum increased in both groups after treat-ment(P＜0.05),and the increase was also significantly higher in the experimental group compared with the control group(P＜0.05).RT-PCR detection of TLR4/NF-κB mRNA content in serum before and after treatment showed that the expression levels of TLR4/NF-κB mRNA in serum decreased significantly after treatment in both groups(P＜0.05),and the decrease was more significant in the experimental group compared with the control group(P＜0.05).Conclusion:The combined treatment of safflower yellow injection and hormones for sudden deafness is sig-nificantly effective,better than monotherapy with western medicine,and can significantly reduce vascular inflamma-tory factors and decrease the expression of the TLR4/NF-κB signaling pathway in patients with sudden deafness.
NETL
NSTL
万方数据
