摘要
目的 观察银翘散对甲型流行性感冒(风热犯卫证)患者的临床疗效,探寻其作用机制.方法 患者200例采用随机数字表法分为治疗组与对照组各100例.对照组接受西医常规治疗,治疗组在对照组基础上加中药颗粒剂银翘散,两组疗程均为5 d.观察两组患者临床症状改善时间、临床疗效及治疗前后两组患者外周血白细胞计数(WBC)、中性粒细胞计数(NEUT)、淋巴细胞计数(LYMP)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平.结果 疗程结束后,治疗组患者体温下降时间、体温恢复至正常时间均明显小于对照组(P＜0.01);治疗组总有效率为91.00％,高于对照组的81.00％(P＜0.05);治疗组患者外周血LYMP明显高于对照组(P＜0.01),血清CRP、TNF-α、IL-6明显低于对照组(P＜0.01).结论 银翘散可显著改善甲型流行性感冒(风热犯卫证)患者发热、咳嗽、咽痛等临床症状,缩短患者病程,减轻炎症反应,抑制病情进展.
Abstract
Objective:To observe the clinical efficacy of Yinqiao powder in the treatment of patients with influ-enza A(syndrome of wind-heat invading Weifen),explore its therapeutic principles.Methods:200 patients were randomly divided into a treatment group and a control group,each with 100 cases.The control group received rou-tine western medical treatment,while the treatment group received additional Chinese herbal granules,specifically Yinqiao powder.The treatment duration for both groups was 5 days.The improvement time of clinical symptoms and clinical efficacy were observed in both groups,as well as changes in peripheral blood white blood cell count(WBC),neutrophil count(NEUT),lymphocyte count(LYMP),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),and interleukin-6(IL-6)levels before and after treatment.Results:At the end of the treatment course,the time for temperature reduction and the time for temperature to return to normal were significantly shorter in the treatment group compared with the control group(P＜0.01),and the overall effective rate was better in the treatment group(P＜0.05).The peripheral blood LYMP in the treatment group was significantly higher than in the control group(P＜0.01),while serum CRP,TNF-α,and IL-6 levels were significantly lower(P＜0.01).Conclu-sion:Yinqiao powder can significantly improve clinical symptoms such as fever,cough,and sore throat in patients with influenza A(syndrome of wind-heat invading Weifen),shorten the course of the disease,reduce inflammatory reactions,and inhibit disease progression.
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