首页|中医药调控VEGF表达干预糖尿病视网膜病变的研究进展

中医药调控VEGF表达干预糖尿病视网膜病变的研究进展

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
  • 维普
血管内皮生长因子(VEGF)可刺激血管内皮细胞生长增殖、诱导迁移、增强血管通透性,并诱导新生血管形成,其水平异常与糖尿病视网膜病变(DR)的进展存在相关性.近年来,随着中医药防治DR的发展和进步,其多靶点、多途径调节VEGF表达的优势受到了广泛的关注.本文通过查阅整理相关文献,发现中医药通过抗VEGF表达干预DR主要依靠绿原酸、胡椒碱、牛蒡子苷等中药有效成分,双丹明目胶囊、芪明颗粒、右归丸等中成药,补阳还五汤、杞菊地黄汤、丹黄明目汤等中药方剂,以及针刺联合中药等方式.本研究归纳VEGF与DR的关系,对中医药通过抑制VEGF表达治疗DR的研究进展进行综述,旨在为临床防治DR提供参考.
Research Progress on Traditional Chinese Medicine Regulating the Expression of VEGF for the Intervention of Diabetic Retinopathy
Vascular endothelial growth factor(VEGF)can stimulate the growth and prolifera-tion of endothelial cells,induce migration,enhance vascular permeability,and induce neovascular-ization.Its abnormal levels are significantly correlated with the progression of diabetic retinopathy(DR).In recent years,with the development and progress of Traditional Chinese medicine(TCM)in preventing and treating DR,the advantages of its multi-target and multi-pathway regulation of VEGF expression have received widespread attention.This article,through reviewing and summa-rizing relevant literature,found that TCM intervenes in DR by targeting VEGF expression mainly through effective components in Chinese medicines such as chlorogenic acid,piperine,arctiin,and Chinese patent medicines like Shuangdan Mingmu Capsule,Qiming Granules,and Yougui Pills.Additionally,TCM formulas such as Buyang Huanwu Decoction,Qiju Dihuang Decoction,and Danhuang Mingmu Decoction,as well as acupuncture combined with Chinese medicines,are employed.This study summarizes the relationship between VEGF and DR and reviews the re-search progress of TCM in treating DR by inhibiting VEGF expression,aiming to provide reference for the clinical prevention and treatment of DR.

Traditional Chinese Medicinediabetic retinopathyvascular endothelial growth factorresearch progress

刘素珍、张花治

展开 >

甘肃中医药大学,兰州 730030

甘肃中医药大学附属医院,兰州 730030

中医药 糖尿病视网膜病变 血管内皮生长因子 研究进展

甘肃省自然科学基金甘肃省中医药科研项目甘肃中医药大学中医学一级学科"岐黄英才"导师专项甘肃省高等学校创新能力提升项目

21JR1RA260GZKP-2021-33ZYXKSD-2022082020A-082

2024

10.13444/j.cnki.zgzyykzz.2024.01.016

中国中医眼科杂志
中国中医科学院

中国中医眼科杂志

CSTPCD
影响因子：0.476
ISSN：1002-4379
年,卷(期)：2024.34(1)
  • 20