摘要
目的 系统评价益气活血类方药联合常规西药治疗青光眼视神经损伤的有效性.方法 检索PubMed、Embase、Web of Science、The Cochrane Library、中国知网、万方和维普数据库报道的益气活血类方药联合常规西药治疗青光眼视神经损伤的相关文献,检索时间为建库至2022年12月1日.对文献进行质量评价后,采用Review Manager 5.4和Stata 14软件对裸眼视力、眼压(IOP)、视野平均敏感度(MS)、视野平均缺损(MD)、图形视觉诱发电位P100潜伏期(LP100)5个结局指标进行Meta分析.结果 共纳入9篇文献,共计746例患者,其中试验组395例,对照组351例.与单纯西药治疗比较,联合益气活血类方药治疗可更有效改善IOP[MD=-1.750,95%CI(-2.900,-0.610),Z=3.000,P=0.003]、MS[MD=3.060,95%CI(2.540,3.580),Z=11.580,P=0.000]、MD[MD=-1.560,95%CI(-1.880,-1.230),Z=9.360,P= 0.000],差异均有统计学意义;但在改善裸眼视力及LP100方面,2组差异无统计学意义(P＞0.05).结论 益气活血类方药联合西药治疗青光眼视神经损伤,可更好地改善该类患者的症状和体征.
Abstract
OBJECTIVE To systematically evaluate the effectiveness of Traditional Chinese Medicine(TCM)tonifying Qi and activating blood in combination with conventional Western Medicine(WM)for treating optic nerve damage in glaucoma.METHODS We searched PubMed,Embase,Web of Science,The Cochrane Library,CNKI,Wanfang,and VIP databases for relevant literature on the combination of tonifying Qi and activating blood TCM with conventional WM for treating optic nerve damage in glaucoma,up to December 1st,2022.After quality assessment,we conducted a meta-analysis using Review Manager 5.4 and Stata 14 software on five outcome measures:Uncorrected visual acuity,intraocular pressure(IOP),mean sensitivity(MS)of the visual field,mean defect(MD)of the visual field,and the latency period of pattern visual evoked potential P100(LP100).RESULTS A total of nine studies involving 746 patients were included,with 395 in the experimental group and 351 in the control group.Compared to the treatment with WM alone,the combined therapy with tonifying Qi and activating blood formulas showed significant improvement in IOP[MD=-1.750,95%CI(-2.900,-0.610),Z=3.000,P=0.003],MD[MD=-1.560,95%CI(-1.880,-1.230),Z=9.360,P=0.000],and MS[MD=3.060,95%CI(2.540,3.580),Z=11.580,P=0.000].However,there was no statistically significant difference between the two groups in improving uncorrected visual acuity and LP100(P>0.05).CONCLUSIONS Combined treatment with tonifying Qi and activating blood formulas and WM for optic nerve damage in glaucoma appears to be more effective in improving symptoms and signs in these patients.
基金项目
国家自然科学基金(82274588)
国家自然科学基金(81904260)
国家自然科学基金(81874492)
湖南省自然科学基金青年基金(2020JJ5436)
中医药防治眼耳鼻咽喉疾病湖南省重点实验室开放基金(2018YZD02)
中医药防治五官科疾病湖南省重点实验室建设项目(2017TP1018)
湖南省教育厅青年项目(2023CX104)
国家科技期刊平台
NSTL
维普
万方数据