The Clinical Study of the Treatment of Allergic Conjunctivitis with Damp-Heat Com-plex Wind Syndrome Using Zhimin Formula Orally Combined with Nebulization
OBJECTIVE To observe the clinical efficacy of oral administration of Zhimin Formula combined with nebulization in the treatment of allergic conjunctivitis(AC)with damp-heat complex wind syndrome.METHODS A total of 90 cases(180 eyes)of AC patients with damp-heat complex wind syndrome treated at Suzhou Hospital of Traditional Chinese Medicine from January 2021 to December 2021 were randomly divided into combined group(CMG),nebulization group(NG),and control group(CG),with 30 cases in each group(60 eyes).The combined group received oral Zhimin Formula and nebulization,the nebulization group received Zhimin Formula nebulization alone,and the control group received eye drops of levocabastine hydrochloride.All groups were treated for 14 days.Symptom scores,sign scores,and tear immunoglobulin E(IgE)antibody level before and after treatment were observed to evaluate clinical efficacy.RESULTS There were no statistically significant differences in symptom scores,sign scores,and tear IgE antibody levels among the three groups before treatment(P>0.05).(1)Symptom scores:After treatment,the symptom scores of all three groups decreased compared to before treatment,and the differences were statistically significant(tCMG =-18.199,tNG=-15.715,tCG=-13.739,all P=0.000).There were significant differences among the three groups after treatment(F=8.594,P=0.000).Compared with the control group,both the combined group and nebulization group had lower symptom scores,with statistically significant differences(tCMG=-3.640,P=0.000;tNG=-3.156,P=0.002).There was no significant difference between the combined group and nebulization group(P>0.05).(2)Sign scores:After treatment,the sign scores of all three groups decreased compared to before treatment,and the differences were statistically significant(tCMG=-18.887,tNG=-17.742,tCG=-15.556,all P=0.000).There were significant differences among the three groups after treatment(F=16.959,P=0.000).Compared with the control group,both the combined group and nebulization group had lower sign scores,with statistically significant differences(tCMG=-5.157,P=0.000;tNG=-4.409,P=0.000).There was no significant difference between the combined group and the nebulization group(P>0.05).(3)Tear IgE antibody:After treatment,the IgE antibody levels of all three groups decreased compared to before treatment,and the differences were statistically significant(tCMG=-48.276,tNG=-38.164,tCG=-34.129,all P=0.000).There were significant differences among the three groups after treatment(F=1937.535,P=0.000).Compared with the control group,both the combined group and nebulization group had lower levels of IgE antibodies(tCMG=-56.682,tNG=-21.667,both P=0.000).The combined group was lower than the nebulization group(t=-49.470,P=0.000),and the differences were statistically significant.(4)Clinical efficacy:There were significant differences in clinical efficacy among the three groups(Z=14.887,P=0.001).Compared with the combined group,both the nebulization group and the control group had lower efficacy(ZNG=-16.483,P= 0.024;ZCG=-23.267,P=0.001),and the differences were statistically significant.There was no significant difference between the nebulization group and the control group(P>0.05).(5)Recurrence rate:There were significant differences in recurrence rates among the three groups(χ2= 22.816,P=0.000).Compared with the control group,both the combined group and nebulization group had lower recurrence rates(χ2CG=22.500,P=0.000;χ2NG=6.696,P=0.010),and the combined group was lower than the nebulization group(χ2=5.963,P=0.015),with statistically significant differences.CONCLUSIONS The combination of oral administration of Zhimin Formula and nebulization is effective in treating AC with damp-heat complex wind syndrome,and it has a significant advantage over single therapy.
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