Association Rule Study of"Syndrome-element-syndrome Pattern"in POAG Based on Data Mining
OBJECTIVE This study aims to explore the distribution characteristics and association rules of Traditional Chinese Medicine(TCM)syndromes,syndrome elements,and syndrome patterns in primary open-angle glaucoma(POAG)based on data mining techniques.METHODS Literature retrieval and compilation were conducted up to December 31st,2022,from Chinese databases including China National Knowledge Infrastructure(CNKI),Wanfang Data,VIP Information,and China Biology Medicine(CBM)database.Clinical studies,case reports,and relevant literature were extracted.Data entry and terminology standardization were performed using Excel software,and the frequency,rate,association rule analysis,and visualization of TCM syndrome elements,syndrome patterns,and syndromes of POAG were conducted using the R language.RESULTS(1)General situation:A total of 70 articles were included,extracting 23 TCM syndrome elements.Among them,the location syndrome elements included eight,with liver being the most frequent(95 times,16.41%),followed by heart spirit(21 times,3.63%),and kidney(20 times,3.45%).There were 15 disease nature syndrome elements,with deficiency syndrome elements being the most Yin deficiency(76 times,13.13%),followed by excessive Yang(57 times,9.84%),Qi stagnation(55 times,9.50%),Qi deficiency(39 times,6.74%),and blood deficiency(39 times,6.74%).A total of 142 TCM syndromes were extracted,with blurred vision being the most frequent(77 times,5.01%),followed by string-like pulse(66 times,4.29%),eye swelling and pain(66 times,4.29%),dizziness(62 times,4.03%),and thin pulse(58 times,3.77%).A total of 31 syndrome patterns were extracted,with liver depression and Qi stagnation pattern being the most frequent,occurring 25 times(35.71%),followed by liver-kidney Yin deficiency pattern(14 times,20%),liver-kidney deficiency pattern(12 times,17.14%),liver depression transforming into fire pattern(11 times,15.71%),and phlegm-dampness internal retention pattern(10 times,14.29%).(2)Analysis of the association rules between syndrome elements and syndromes:The combinations with higher association between syndrome elements are blood deficiency,Yang deficiency-Qi deficiency,Yang deficiency-Qi deficiency,spleen-Qi deficiency.The combinations with higher association between syndromes are yellow tongue coating-red tongue color,string-like pulse,yellow tongue coating-red tongue color,bitter taste in the mouth,yellow tongue coating-red tongue color.The combinations with higher association between syndrome elements and syndromes are bitter taste,rapid pulse,string-like pulse,yellow tongue coating,red tongue color-heat,bitter taste in the mouth,string-like pulse,yellow tongue coating,red tongue color,reduced appetite-heat,bitter taste in the mouth,rapid pulse,string-like pulse,emotional depression,red tongue color-heat.(3)Distribution patterns of core syndrome elements:Bitter taste in the mouth,dry throat,and string-like pulse are closely related to all core syndrome elements.CONCLUSIONS POAG is characterized by liver as the core location syndrome element,and common disease nature syndrome elements include Yin deficiency,excessive Yang,Qi stagnation,and Qi deficiency.There is a strong correlation between syndrome elements,and each core syndrome element has characteristic systemic syndromes,providing theoretical support for accurate differentiation of POAG.
primary open angle glaucomasyndrome elementdata miningassociation rulesR language
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