A Meta-analysis of the Therapeutic Efficacy and Safety of Rat Nerve Growth Factor in Non-Arteritic Anterior Ischemic Optic Neuropathy
OBJECTIVE To conduct a Meta-analysis on the efficacy and safety of rat nerve growth factor(mNGF)in the treatment of non-arteritic anterior ischemic optic neuropathy(NAION).METHODS Randomized controlled trial(RCT)reporting the use of mNGF in treating NAION were retrieved from PubMed,Web of Science,The Cochrane Library,China National Knowledge Infrastructure(CNKI),Wanfang,VIP,and China Biology Medicine Database(CBM)databases up to February 2023.The studies were categorized into treatment and control groups based on the use of mNGF.Two researchers independently screened literature,extracted data,assessed the risk of bias in the included studies,and conducted a Meta-analysis using RevMan 5.3 software on the overall effective rate,visual acuity,visual field,electro-physiological P100 peak latency,and average thickness of the optic nerve fiber layer.Safety was also evaluated.RESULTS A total of 18 articles with 1,507 patients(1,573 eyes)were included,comprising 759 cases(797 eyes)in the treatment group and 748 cases(776 eyes)in the control group.The treatment group,using mNGF,showed significantly higher overall effective rate[OR=4.810,95%CI(3.480,6.650),Z=9.540,P= 0.000],visual acuity[MD=0.120,95%CI(0.080,0.170),Z=5.430,P=0.000],average visual field defect degree[MD=-1.960,95%CI(-2.560,-1.360),Z=6.400,P=0.000],electro-physiological P100 peak latency[MD=-8.650,95%CI(-11.610,-5.700),Z=5.740,P=0.000],and average thickness of the optic nerve fiber layer[MD=10.420,95%CI(8.300,12.540),Z=9.650,P=0.000]compared to the control group,with statistically significant differences.Adverse reactions were primarily mild local stimulation,pain,and induration following local mNGF injection.CONCLUSIONS The mNGF treatment for NAION demonstrates certain efficacy,improving the overall effective rate,visual acuity,and reducing the average visual field defect degree and average thickness of the optic nerve fiber layer.Its clinical application is deemed safe and reliable.
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万方数据
维普
