干性年龄相关性黄斑变性中西医治疗研究进展
Research Progress on Treatment of Dry Age-Related Macular Degeneration in Tradi-tional Chinese Medicine and Western Medicine
孙婉钰 1李欣 1张红1
作者信息
- 1. 中国中医科学院眼科医院,北京 100040
- 折叠
摘要
年龄相关性黄斑变性(AMD)是导致老年人致盲的常见性眼病,随着全球人口老龄化的加剧,AMD已成为全球性问题.根据眼底的不同表现,AMD在可分为2种类型,即干性AMD(dAMD)和湿性AMD(wAMD).抗血管内皮生长因子作为一线药物治疗wAMD已取得显著疗效,而dAMD尚无明确的治疗方法 .本文通过梳理国内外文献,针对dAMD的中、西医治疗进展进行综述,发现西医治疗主要包括补体抑制、神经保护、基因治疗、干细胞治疗、抗炎、抗氧化治疗等;中医治疗本病主要从肝、脾、肾出发,病证结合、辨证论治.但目前研究样本量均较小,尚缺乏大样本、多中心随机对照试验为本病的治疗提供有力的证据支持.
Abstract
Age-related macular degeneration(AMD)is a common cause of blindness in the elderly population,and with the aging of the global population,AMD has become a global issue.According to different manifestations in the fundus,AMD can be divided into two types:Dry AMD(dAMD)and wet AMD(wAMD).Anti-vascular endothelial growth factor therapy has shown signifi-cant efficacy as a first-line treatment for wAMD,while there is still no definitive treatment for dAMD.This article reviews the progress of Traditional Chinese Medicine(TCM)and Western Medicine treatments for dAMD by reviewing domestic and foreign literature.It was found that Western Medicine treatments mainly include complement inhibitors,neuroprotective agents,gene therapy,stem cell therapy,anti-inflammatory medicines,and antioxidants.TCM treatment for this disease mainly starts from liver,spleen,and kidney,combining syndrome differentiation with treat-ment.However,current research samples are relatively small,and there is a lack of large-sample,multicenter randomized controlled trials to provide strong evidence support for the treatment of this disease.
关键词
干性年龄相关性黄斑变性/中医/西医/辨证论治Key words
dry age-related macular degeneration/Traditional Chinese Medicine/Western Medicine/syndrome differentiation and treatment引用本文复制引用
基金项目
北京市中医药"薪火传承3+3工程"项目()
中国中医科学院科技创新工程项目(CI2021A05405)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据