Meta-analysis of Traditional Chinese Medicine for the Treatment of Myopia in Ado-lescents
OBJECTIVE To evaluate the clinical efficacy and safety of Traditional Chinese Medicine(TCM)for the treatment of myopia in adolescents.METHODS PubMed,Embase,Web of Science,The Cochrane Library,China National Knowledge Infrastructure(CNKI),Wanfang,and VIP databases were searched for randomized controlled trials(RCTs)on TCM treatment(regardless of treatment regimen and course)for myopia until December 31st,2022.The quality of included studies was assessed using the modified Jadad scale and Cochrane bias risk assessment tool.Statistical analysis was performed using Review Manager 5.4.1 and Stata 17.0 software.RESULTS A total of 33 studies involving 3,134 patients(6,056 eyes)were included;of these,the treatment group using TCM included 1,576 cases(3,048 eyes),and the control group receiving conventional myopia control included 1,558 cases(3,008 eyes).Compared with the control group,patients in the treatment group showed more significant efficacy in improving the total effective rate[OR=4.580,95%CI(3.290,6.380),Z=9.030,P=0.000],improving uncorrected visual acuity[SMD=0.560,95%CI(0.310,0.810),Z=4.350,P=0.000],reducing diopter[MD=0.240,95%CI(0.080,0.400),Z=2.940,P=0.003],and delaying axial elongation[MD=-0.080,95%CI(-0.150,-0.010),Z=2.070,P= 0.040],with all differences statistically significant;however,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).CONCLUSIONS Compared with conventional myopia control,TCM is more effective in improving the total effective rate,improving uncorrected visual acuity,reducing diopter,and slowing axial elongation.However,its safety needs further clinical validation.
adolescent myopiaTraditional Chinese Medicinerandomized controlled trialsafety
万方数据
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