Influence of Shufeng Qingre Formula Nebulization on Blink-related Visual Quality in Patients with Lipid Abnormality-related Dry Eye
OBJECTIVE To observe the Shufeng Qingre Formula nebulization on blink-related visual quality in patients with lipid abnormality-related dry eye.METHODS A total of 72 patients diagnosed with lipid abnormality-related dry eye,characterized by wind-heat pattern,were included from January 2022 to January 2023 at the Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine.They were randomly divided into a control group(CG)and an observation group(OG),each comprising 36 cases.The control group received treatment with hydroxypropyl guar eye drops,while the observation group received combined treatment of Shufeng Qingre Formula nebulization in addition to the treatment provided in the control group.Both groups were treated for four weeks.Ocular Surface Disease Index(OSDI)scores,non-invasive first break-up time(NIF-BUT),non-invasive average break-up time(NIAVG-BUT),order aberrations of visual quality measured and statistically analyzed before and after treatment.RESULTS Before treatment,there were no significant differences in OSDI scores,NIF-BUT(NB),NIAVG-BUT(NIB),and visual quality at blink 0 s and 10 s between the two groups(P>0.05).(1)OSDI scores:After treatment,OSDI scores in both groups decreased significantly compared to before treatment(tOG=7.740,P=0.000;tCG=2.619,P=0.010).The observation group had lower OSDI scores than the control group after treatment(t=6.668,P=0.000).(2)NIF-BUT,NIAVG-BUT:After treatment,both NIF-BUT and NIAVG-BUT in both groups prolonged significantly compared to before treatment(NIF-BUT:ZOG=7.374,ZCG=11.237,both P=0.000;NIAVG-BUT:ZOG=5.940,ZCG=3.408,both P=0.000).The observation group had longer NIF-BUT and NIAVG-BUT than the control group after treatment(ZNB=5.892,ZNIB=6.949,both P= 0.000).(3)Visual quality at blink 0 s:After treatment,all order aberrations of visual quality decreased significantly in both groups compared to before treatment[total HOAs(TH):ZOG=6.489,ZCG=3.306,both P=0.000;fourth-order spherical aberration(FOSA):ZOG=7.961,ZCG=4.026,both P= 0.000;third-order coma(TOC):ZOG=5.008,ZCG=4.170,both P=0.000;trefoil:ZOG=5.669,ZCG== 3.410,both P=0.000].The observation group had lower order aberrations than the control group after treatment(ZTH=4.735,ZFOSA=6.578,ZTOC=4.055,Ztrefoil=3.846,all P=0.000).(4)Visual quality at blink 10 s:After treatment,total HOAs root mean square,third-order coma,and trefoil decreased significantly in both groups compared to before treatment(total HOAs:ZOG=6.256,ZCG= 3.487,both P=0.000;third-order coma:ZOG=3.880,ZCG=3.849,both P=0.000;trefoil:ZOG=4.048,P=0.000;ZCG=2.328,P=0.020).The observation group showed a decrease in fourth-order spherical aberration after treatment compared to before treatment(Z=3.361,P=0.000),whereas the control group did not exhibit a significant difference(P>0.05).The observation group had lower total HOAs root mean square and third-order coma than the control group after treatment(ZTH=5.129,ZTOC=3.219,both P=0.000),whereas the fourth-order spherical aberration and trefoil did not exhibit a significant difference between groups(P>0.05).CONCLUSIONS Shufeng Qingre Formula can improve the blink-related visual quality in patients with lipid abnormality-related dry eye.
Shufeng Qingre Formulalipid abnormality-related dry eyeblinkvisual qual-ityhigher order aberrations
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