Observation of the Therapeutic Effect of Shujian Runmu Formula Nebulization on Meibomian Gland Dysfunction-related Dry Eye with Damp-heat Accumulation
OBJECTIVE To observe the clinical efficacy of Shujian Runmu Formula nebulization in the treatment of mild to moderate meibomian gland dysfunction(MGD)-related dry eye with damp-heat accumulation.METHODS A total of 60 patients(120 eyes)diagnosed with mild to moderate MGD-related dry eye were included from July 2021 to June 2022 at Suzhou Hospital of Traditional Chinese Medicine(TCM).They were randomly divided into a treatment group(TG)and a control group(CG),each consisting of 30 patients(60 eyes),characterized by damp-heat accumulation.The control group received treatment including eyelid margin cleaning,nebulization,meibomian gland massage,carbomer eye gel,and sodium diclofenac eye drops.The treatment group substituted 0.9%sodium chloride injection in the control group with a decoction of Shujian Runmu Formula,following the same treatment as the control group.Both groups were treated for 30 days.Tear film break-up time(BUT),corneal fluorescein staining(FL)scores,ocular surface disease index(OSDI)scores,number of secreting meibomian glands,meibomian gland secretion scores,and tear pH were measured before and after treatment.RESULTS Before treatment,there were no significant differences in BUT,FL scores,OSDI scores,number of secreting meibomian glands,meibomian gland secretion scores,and tear pH between the two groups(P>0.05).(1)BUT:After treatment,BUT in both groups was significantly prolonged compared to before treatment(tTG=26.000,tCG= 15.480,both P=0.000).BUT in the treatment group was longer than in the control group after treatment,showing statistical significance(t=9.936,P=0.000).(2)FL scores:After treatment,FL scores in both groups were significantly lower than before treatment(tTG=20.330,tCG=9.181,both P= 0.000).The FL scores in the treatment group were lower than in the control group after treatment,demonstrating statistical significance(t=5.543,P=0.000).(3)OSDI scores:After treatment,OSDI scores in both groups were significantly lower than before treatment(tTG=16.093,tCG=5.435,both P= 0.000).The OSDI scores in the treatment group were lower than those in the control group after treatment,indicating statistical significance(t=3.440,P=0.001).(4)Number of secreting meibomian glands:After treatment,the number of secreting meibomian glands in both groups increased significantly compared to before treatment(tTG=12.400,tCG=8.484,both P=0.000).The treatment group had a higher number of secreting meibomian glands than the control group after treatment,showing statistical significance(t=3.216,P=0.002).(5)Meibomian gland secretion scores:After treatment,the meibomian gland secretion scores in both groups were significantly lower than those before treatment(tTG=8.510,P=0.000;tCG=2.100,P=0.038).The meibomian gland secretion scores in the treatment group were lower than those in the control group after treatment,indicating statistical significance(t=5.294,P=0.000).(6)Tear pH:After treatment,tear pH in both groups were significantly lower than those before treatment(tTG=26.602,tCG=16.763,both P= 0.000).Tear pH in the treatment group was lower than that in the control group after treatment,demonstrating statistical significance(t=7.058,P=0.000).CONCLUSIONS Shujian Runmu Formula nebulization can alleviate symptoms,and enhance meibomian gland function in patients with mild to moderate MGD-related dry eye with damp-heat accumulation.
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