OCTA对视网膜色素变性诊断及管理价值的Meta分析
Meta-analysis of OCTA's Diagnostic and Management Value in Retinitis Pigmentosa
赵巧 1巢国俊 1杨海静 1王雪瑶1
作者信息
- 1. 中国中医科学院眼科医院,北京 100700
- 折叠
摘要
目的 使用Meta分析评价光学相干断层扫描血管成像(OCTA)在视网膜色素变性(RP)患者中的诊断及管理价值.方法 检索PubMed、Embase、中国知网、万方、维普、中国生物医学文献(CBM)数据库中对RP患者应用OCTA的相关文献,检索时间为建库至2023年9月30日,选择中央凹无血管区(FAZ)面积、浅层毛细血管丛(SCP)和深层毛细血管丛(DCP)的血流密度(VD)、脉络膜VD作为结局指标,采用Stata 15.0软件进行统计分析.结果 (1)纳入文献情况:共纳入18项研究,RP组500例患者(695只眼),健康对照组458例患者(546只眼).(2)FAZ面积:RP组患者SCP层和DCP层的FAZ面积均大于健康对照组,差异有统计学意义[SCP层:WMD=0.100,95%CI(0.063,0.136),Z=5.320,P=0.000;DCP层:WMD= 0.162,95%CI(0.069,0.255),Z=3.400,P=0.001].(3)视网膜微循环:RP组患者在黄斑整体、中心凹、旁中心凹、周围区的SCP层和DCP层的VD均低于健康对照组,差异均有统计学意义(均P＜0.05).(4)脉络膜微循环:RP组患者整体VD及旁中心凹VD均低于健康对照组,差异有统计学意义[整体VD:WMD=-2.383,95%CI(-4.152,-0.614),Z=2.640,P=0.000;旁中心凹VD:WMD=-3.177,95%CI(-4.956,-1.398),Z=3.530,P=0.000].2组中心凹VD比较,差异无统计学意义(P＞0.05).结论 OCTA在RP患者视网膜SCP层及DCP层的FAZ面积,黄斑整体、中心凹、旁中心凹、周围区VD及脉络膜黄斑区VD方面的检测结果较健康人群有明显的差异性,OCTA有希望成为诊断及管理RP患者的可靠工具.
Abstract
OBJECTIVE To evaluate the diagnostic and management value of optical coherence tomography angiography(OCTA)in patients with retinitis pigmentosa(RP)through Meta-analysis.METHODS Relevant literature on RP patients using OCTA was searched in PubMed,Embase,CNKI,Wanfang,VIP,and CBM databases from inception to September 30th,2023.Central foveal avascular zone(FAZ)area,vascular density(VD)of superficial capillary plexus(SCP)and deep capillary plexus(DCP),and choriocapillaris VD were selected as outcome measures.Statistical analysis was performed using Stata 15.0 software.RESULTS(1)Included studies:A total of 18 studies were included,comprising 500 RP patients(695 eyes)in the RP group and 458 healthy control patients(546 eyes)in the control group.(2)FAZ area:The FAZ area in both SCP and DCP layers was larger in the RP group than in the healthy control group,with statistically significant differences[SCP layer:WMD=0.100,95%CI(0.063,0.136),Z=5.320,P=0.000.DCP layer:WMD=0.162,95%CI(0.069,0.255),Z=3.400,P= 0.001].(3)Retinal microcirculation:The VD of SCP and DCP layers in the macula,central fovea,parafoveal region,and peripheral area were lower in the RP group than in the healthy control group,with statistically significant differences(all P<0.05).(4)Choriocapillaris microcirculation:The overall VD and parafoveal VD in the RP group were lower than those in the healthy control group,with statistically significant differences[overall VD:WMD=-2.383,95%CI(-4.152,-0.614),Z=2.640,P=0.000;Parafoveal VD:WMD=-3.177,95%CI(-4.956,-1.398),Z=3.530,P=0.000].There was no statistically significant difference in central foveal VD between the two groups(P>0.05).CONCLUSIONS OCTA shows good discriminatory ability in detecting FAZ area in SCP and DCP layers,VD in macula,central fovea,parafoveal region,and peripheral area,as well as choriocapillaris VD in RP patients compared to healthy individuals.OCTA holds promise as a reliable tool for diagnosing and managing RP patients.
关键词
光学相干断层扫描血管成像/视网膜色素变性/黄斑/诊断价值/管理价值Key words
optical coherence tomography angiography/retinitis pigmentosa/macula/diag-nostic value/management value引用本文复制引用
基金项目
国家中医药管理局国家中医临床研究基地业务建设科研专项课题(JDZX2015285)
中国中医科学院"名医名家传承"项目(CI2021A02611)
出版年
2024
国家科技期刊平台
NSTL
万方数据