Research on Medication Patterns for Treating Vitreous Opacity(Moving Clouds and Mists)in Ancient Chinese Medical Books Based on Data Mining
OBJECTIVE To analyze the medication patterns for treating vitreous opacity(moving clouds and mists)in ancient Chinese medical books using data mining techniques.METHODS Relevant records of vitreous opacity in ancient Chinese medical books were reviewed in Certification and Standardization of Chinese Medical Terms.Formulas related to treating vitreous opacity were collected and organized from ancient Chinese medical books.The relevant information of these formulas was entered into Excel software.SPSS Modeler 18.0,Cytoscape 3.9.1,and SPSS 25.0 software were utilized for multidimensional analysis of 68 formulas from 16 ancient Chinese medical books for treating vitreous opacity.The analysis included medication frequency,properties and flavors,high-frequency medicinal effects,association rules,cluster analysis,and complex network analysis.RESULTS(1)General situation:A total of 68 formulas were included,involving 153 Chinese medicines,with a total frequency of 709 occurrences,including 27 medicines with a frequency of≥10 times.(2)Properties and flavors:The total frequency of medicinal properties was 153 times,with cold and warm properties being the most frequently used(both 37 times,24.18%);The total frequency of flavors was 247 times,with sweet flavors being the most frequently used(70 times,28.34%);The total frequency of medicinal channels was 374 times,with medicines that entered liver channel being the most frequently used(78 times,20.86%).(3)High-frequency medicinal analysis:The top five most frequently used medicines were Chrysanthemum(24 times,3.39%),Saposhnikovia divaricata(20 times,2.82%),Rhizoma seu Radix Notopterygii(19 times,2.68%),Plantago asiatica(17 times,2.40%),and Poria cocos(17 times,2.40%).(4)Association rule analysis:The top five strong association pairs of medicines based on confidence level were Poria cocos-Alisma orientale,Cistanche deserticola-Cuscuta chinensis,Poria cocos-Dioscorea opposita,Tribulus terrestris-Desmodium styracifolium,Chrysanthemum-Desmodium styracifolium;The top five strong association triads of medicines were Saposhnikovia divaricata-Asarum sieboldii-Cassia tora,Saposhnikovia divaricata-Plantago asiatica-Cassia tora,Asarum sieboldii-Astragalus membranaceus-Cassia tora,Astragalus membranaceus-Asarum sieboldii-Cassia tora.(5)Cluster analysis:A total of seven core medicinal groups were obtained,including tonifying liver and kidney,nourishing Qi and blood,activating meridians and calming liver and extinguishing wind,activating meridians and clearing heat,activating meridians and promoting diuresis and relieving dampness,clearing heat and calming liver and extinguishing wind and tonifying Qi,and clearing heat.(6)Complex network analysis:The core medicines were Saposhnikovia divaricata,Chrysanthemum,Poria cocos,Glycyrrhiza uralensis,Ligusticum chuanxiong,and Tribulus terrestris,with high frequency of use and strong associations with other medicines.CONCLUSIONS The core medicines for treating vitreous opacity in ancient Chinese medical books mainly include Cistanche deserticola,Cuscuta chinensis,and other tonifying medicines,focusing on liver and kidney deficiency as the main pathogenesis.The treatment principle emphasizes tonifying liver and kidney,nourishing Qi and blood while dispersing wind,combined with syndrome differentiation,and supplemented with heat-clearing and diuresis-promoting methods,with flexible medication.
data miningancient Chinese medical booksmoving clouds and mistsmedica-tion patternsvitreous opacity
万方数据
维普
