Effects of Tiluo Yangxue Mingmu Decoction on Ocular Blood Flow in Patients with Normal-Tension Glaucoma
OBJECTIVE To observe the effects of Tiluo Yangxue Mingmu Decoction on ocular blood flow in patients with normal-tension glaucoma(NTG).METHODS A total of 32 NTG patients(63 eyes),diagnosed with blood stasis obstruction pattern,treated at the Eye Hospital of China Academy of Chinese Medical Sciences from June 2018 to December 2021,were randomly divided into a treatment group(20 cases,39 eyes)and a control group(12 cases,24 eyes).The control group received oral administration of Ginkgo biloba leaf extract and mecobalamin tablets,while the treatment group received Tiluo Yangxue Mingmu Decoction in addition to the control group's treatment.Both groups were observed for 28 days.Ocular blood flow parameters including vessel density(VD1 and VD2)in the total optic nerve head scan area,peak systolic velocity(PSV),end-diastolic velocity(EDV),and resistance index(RI)of the central retinal artery(CRA)and short posterior ciliary artery(SPCA)were measured before and after treatment.RESULTS There were no significant differences in VD1,VD2,EDV,PSV,and RI between the two groups before treatment(P>0.05).Additionally,there were no significant differences in VD1,VD2,CRA,and SPCA PSV,EDV,and RI between before and after treatment in the control group(P>0.05).(1)VD:After treatment,VD1 and VD2 in the treatment group were significantly increased compared to before treatment(tVD1=6.739,tVD2=8.285,both P=0.000).There were no significant differences in VD1 and VD2 between the two groups after treatment(P＞0.05).The difference values of VD1 and VD2 before and after treatment in the treatment group were significantly higher than those in the control group(tVD1=5.599,tVD2=6.210,both P=0.000).(2)Regarding ocular vascular hemodynamic parameters:In terms of ocular blood flow parameters,EDV of CRA in the treatment group after treatment was significantly increased,and RI was significantly decreased compared to before treatment(tEDV=3.096,P=0.003;tRI=2.446,P=0.017).There were no significant differences in all indicators of CRA between the two groups after treatment(P＞0.05).PSV and EDV of SPCA in the treatment group after treatment were significantly increased compared to before treatment(tPSV=2.481,P=0.015;tEDV=2.315,P=0.023).There were no significant differences in all indicators of SPCA between the two groups after treatment(P＞0.05).CONCLUSIONS Tiluo Yangxue Mingmu Decoction can improve ocular blood flow in patients with NTG,especially in the optic nerve blood flow.
万方数据
维普
