Clinical Efficacy of Houttuynia Cordata Eye Drops Nebulization Combined with Mei-bomian Gland Massage in Treating Meibomian Gland Dysfunction-related Dry Eye
OBJECTIVE To observe the clinical efficacy of Houttuynia Cordata eye drops nebulization combined with meibomian gland massage in treating meibomian gland dysfunction(MGD)-related dry eye.METHODS A total of 160 patients(160 eyes)diagnosed with MGD-related dry eye in Beijing Huairou Hospital of Traditional Chinese Medicine from January 2022 to December 2022 were included.They were randomly divided into a control group(CG)and an observation group(OG),with 80 cases(80 eyes)in each group,all of which were treated with the right eye.The control group received meibomian gland massage combined with 0.1％sodium hyaluronate eye drops.The observation group received Houttuynia Cordata eye drops nebulization in addition to the treatment in the control group.Both groups were treated for four weeks.Clinical symptom scores,ocular surface disease index(OSDI)scores,tear film breakup time(BUT),Schirmer Ⅰ test(SⅠT),and lower tear meniscus height(LTMH)were measured before and after treatment.RESULTS There was no significant difference in clinical symptom scores,OSDI scores,BUT,SⅠT,and LTMH between the two groups before treatment(P>0.05).(1)Clinical symptom scores:After treatment,the clinical symptom scores in both groups were significantly reduced compared to before treatment,and the differences were statistically significant(tOG=18.441,tCG=9.932,both P=0.000).The clinical symptom scores in the observation group were lower than those in the control group after treatment,and the difference was statistically significant(t=2.315,P=0.022).(2)OSDI scores:After treatment,the OSDI scores in both groups were significantly reduced compared to before treatment,and the differences were statistically significant(tOG=15.043,tCG=16.841,both P=0.000).The OSDI scores in the observation group were lower than those in the control group after treatment,and the difference was statistically significant(t=3.240,P=0.001).(3)BUT:After treatment,the BUT in both groups was significantly increased compared to before treatment,and the difference was statistically significant(tOG=14.272,tCG=12.071,both P=0.000).The BUT in the observation group was higher than that in the control group after treatment,and the difference was statistically significant(t=4.421,P=0.000).(4)SⅠT:After treatment,the SⅠT in both groups was significantly increased compared to before treatment,and the differences were statistically significant(tOG=18.611,tCG=11.224,both P=0.000).The SⅠT in the observation group was higher than that in the control group after treatment,and the difference was statistically significant(t=5.827,P=0.000).(5)LTMH:After treatment,the LTMH in both groups was significantly increased compared to before treatment,and the differences were statistically significant(tOG=13.151,tCG=8.374,both P=0.000).The LTMH in the observation group was higher than that in the control group after treatment,and the difference was statistically significant(t=3.492,P=0.001).(6)Clinical efficacy:The total effective rate in the observation group was higher than that in the control group,and the difference was statistically significant(χ2=10.030,P=0.002).CONCLUSIONS Houttuynia Cordata eye drops nebulization combined with meibomian gland massage can improve MGD-related dry eye symptoms,increase tear secretion,prolong BUT,and enhance tear film stability.
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