Analysis of Medication Patterns in Patent Traditional Chinese Medicine Formulas for Diabetic Retinopathy Treatment Based on Data Mining
OBJECTIVE To analyze the medication patterns in patented Traditional Chinese Medicine(TCM)formulas for the treatment of diabetic retinopathy(DR)using data mining methods,providing reference for optimizing clinical prescriptions and developing new patents.METHODS Patents related to TCM interventions for DR were selected from the China Patent Publication Announcement Database of the National Intellectual Property Administration up to July 10th,2023.The item Frequency function,Apriori algorithm,and hclust package in R language were used for frequency statistics,association rule analysis,and cluster analysis,respectively The results were visualized using the arulesViz package,and core prescriptions were identified using Cytoscape.RESULTS(1)General overview:A total of 96 patented TCM formulas,involving 253 Chinese medicines,were included.(2)Frequency of use:There were 29 Chinese medicines with a usage frequency of more than 10 times(high-frequency Chinese medicines),with the top five Chinese medicines being Rehmanniae Radix(54 times,21.34%),Notoginseng Radix(44 times,17.39%),Astragali Radix(43 times,16.99%),Angelicae Sinensis Radix(41 times,16.20%),and Lycii Fructus(36 times,14.22%).(3)Chinese medicines properties:In terms of the four Qi,cold(101 times,40.00%)was the most common.Among the five tastes,sweet(104 times,41.12%)was the most common.In terms of meridian tropism,liver meridian(89 times,35.17%)was the most common.(4)Chinese medicines association analysis:The top five Chinese medicines pairs with the highest correlations were Cuscutae Semen-Plantaginis Semen,Cassiae Semen-Leonuri Semen,Ganoderma-Semen Torreyae,Buddlejae Flos-Coptidis Rhizoma,and Cassiae Semen-Celosiae Semen.(5)Cluster analysis:Five clusters of Chinese medicines were identified.Cluster I:Disperses wind and clearing heat,nourishing liver,and improving vision.Cluster II,Nourishing Yin and clearing heat.Cluster III,Tonifing liver and kidney,and improves vision.Cluster IV,Invigoratingblood and removing stasis.Cluster V,Tonifing Qi and Yin,invigorating blood,and unblocking the collaterals.(6)Core TCM prescription:One core prescription was identified,including Dioscoreae Rhizoma,Lycii Fructus,Astragali Radix,Rehmanniae Radix,Dendrobii Caulis,Glycyrrhizae Radix,Cuscutae Semen,and Ophiopogonis Radix.CONCLUSIONS The basic treatment principles for DR with TCM are to tonify Qi and Yin,invigorate blood,and unblock collaterals.Blood-invigorating and deficiency-tonifying Chinese medicines are frequently used,with different Chinese medicines selected for various concomitant symptoms.The new prescription can be applied to different stages of the disease.
diabetic retinopathyTraditional Chinese Medicine formuladata miningna-tional patentmedication pattern
万方数据
维普
