Observation of the Efficacy of Shugan Yangxue Runmu Acupuncture Method in Treating Aqueous Deficient Dry Eye
OBJECTIVE To observe the clinical efficacy and safety of Shugan Yangxue Runmu acupuncture method in treating aqueous deficient dry eye(ATD).METHODS A total of 98 ATD patients(196 eyes)treated at Tangshan Fengrun People's Hospital from June 2021 to June 2023 were included.They were randomly divided into a control group(CG)and a treatment group(TG)using a random number table,with 48 patients(96 eyes)in each group.The control group received 1.4% polyvinyl alcohol eye drops,while the treatment group received Shugan Yangxue Runmu acupuncture method in addition to the control group treatment.Both groups were observed for four weeks.The tear film break-up time(BUT),SchirmerⅠ test(SⅠT),corneal fluorescein staining(FL),the level of interleukin(IL)-1β,IL-6 and matrix metalloproteinase-9(MMP-9),and Traditional Chinese Medicine(TCM)symptom scores were measured before and after treatment.RESULTS(1)BUT:After treatment,BUT in both groups was significantly longer than before treatment(tTG=50.217,tCG=40.909,both P=0.000).The treatment group's BUT was longer than the control group's after treatment,with a statistically significant difference(t=7.349,P=0.000).(2)SⅠT:After treatment,SⅠT in both groups was significantly longer than before treatment(tTG=46.149,tCG=42.726,both P=0.000).The treatment group's SⅠT was longer than the control group's after treatment,with a statistically significant difference(t=7.078,P=0.000).(3)FL:After treatment,FL in both groups was significantly lower than before treatment(tTG=50.398,tCG=42.955,both P=0.000).The treatment group's FL was lower than the control group's after treatment,with a statistically significant difference(t=8.688,P=0.000).(4)Tear inflammatory factors:After treatment,IL-1β,IL-6,and MMP-9 levels in both groups were significantly lower than before treatment(IL-1β:tTG=71.214,tCG=51.982,both P=0.000;IL-6:tTG=83.398,tCG=70.133,both P=0.000;MMP-9:tTG=673.908,tCG=623.730,both P=0.000).The treatment group's IL-1β,IL-6,and MMP-9 levels were lower than the control group's after treatment,with statistically significant differences(tIL-1β=10.708,tIL-6=9.689,tMMP-9=9.155,all P=0.000).(5)TCM syndrome scores:After treatment,TCM symptom scores in both groups were significantly lower than those before treatment(tTG=54.729,tCG=46.822,both P=0.000).The treatment group's TCM symptom scores were lower than those in the control group's after treatment,with a statistically significant difference(t=11.622,P=0.000).(6)Clinical efficacy:The overall effective rate was 92.71% in the treatment group,higher than 82.29% in the control group,with a statistically significant difference(χ2=4.762,P=0.029).(7)Adverse effects:There was no statistically significant difference in adverse reactions between the two groups(P>0.05).CONCLUSIONS For ATD patients,Shugan Yangxue Runmu acupuncture method combined with artificial tears can effectively alleviate symptoms,significantly improve tear film stability indicators such as FL,and has high safety.
NETL
NSTL
万方数据
