Exploring the Prescription Patterns of Traditional Chinese Medicine in the Treatment of Retinal Vein Occlusion with Macular Edema Based on Data Mining
OBJECTIVE To apply the R language data mining platform to mine the prescription information of Traditional Chinese Medicine(TCM)for the treatment of retinal vein occlusion secondary to macular edema(RVO-ME),and to provide a new direction of thinking for the treatment of RVO-ME by TCM.METHODS Literature related to the TCM treatment of RVO-ME was collected from CNKI,Wanfang,VIP,and CBM databases from their inception to September 30th,2023.The literature was screened according to inclusion and exclusion criteria,and prescription information was extracted.After standardizing the names of the Chinese medicines,data was statistically analyzed using R language(version 4.1.1).The ggplot 2 function was employed for frequency analysis,and bar charts were created to display the most frequently used Chinese medicines in the treatment of RVO-ME.The arules and arulesViz functions were used for association analysis.Hierarchical clustering was performed on the data using clustering algorithms,with the NbClust function selecting the optimal number of clusters for further analysis.RESULTS(1)Properties of Chinese medicines:A total of 42 articles were included,comprising 43 prescriptions and involving 92 Chinese medicines,with a cumulative frequency of 487 times.The four properties of Chinese medicines showed that warm Chinese medicines were the most common,with 151 times(31.01%).The five flavors were predominantly sweet,with 173 times(35.52%).Chinese medicines that entered liver meridian were used the most frequently,with 128 times(26.28%).(2)Frequency of high-frequency Chinese medicines:A total of 30 Chinese medicines were used more than five times(high-frequency Chinese medicines).The top five were Poria cocos(34 times,79.07%),Angelica sinensis(26 times,60.47%),Atractylodes macrocephala(21 times,48.84%),Ligusticum chuanxiong(21 times,48.84%),and Alisma orientale(21 times,48.84%).(3)TCM association rules analysis:The top five pairs of Chinese medicines with the highest association were Angelica sinensis-Poria cocos;Alisma orientale-Poria cocos;Atractylodes macrocephala-Poria cocos;Ligusticum chuanxiong-Angelica sinensis;Ligusticum chuanxiong-Poria cocos.(4)High-frequency Chinese medicines clustering analysis:Four clusters of prescriptions were identified.The efficacy of cluster I is to invigorate blood circulation,unblock collaterals,promote diuresis,and drain dampness.Cluster Ⅱ aims to promote blood circulation,remove blood stasis,tonify Qi,and strengthen the spleen.Cluster Ⅲ focuses on warming Yang and promoting diuresis.Cluster Ⅳ emphasizes nourishing Yin,enriching the blood,promoting blood circulation,and regulating Qi.CONCLUSIONS The TCM treatment principles for RVO-ME emphasize the simultaneous treatment of blood and water,focusing on invigorating blood circulation,removing blood stasis,promoting diuresis,draining dampness,tonifying Qi,and strengthening spleen.
retinal vein occlusion with macular edemaprescription patternsdata mining
NETL
NSTL
万方数据
