Observing the Efficacy of Micro-acupoint Ear Acupuncture Combined with Botuli-num Toxin Type A in Treating Benign Essential Blepharospasm with Anxiety and Depres-sion
OBJECTIVE To observe the clinical efficacy of micro-acupoint ear acupuncture combined with botulinum toxin type A(BTX-A)in treating benign essential blepharospasm(BEB)complicated by anxiety and depression.METHODS From December 2021 to December 2022,a total of 63 patients(126 eyes)with BEB and anxiety or depression were treated at the Ophthalmology and Neurology Outpatient Departments of Foshan Hospital of Traditional Chinese Medicine.The patients were randomly divided into three groups using a random number table method:The botulinum toxin group(BTG),the ear acupuncture group(EAG),and the combined treatment group(CTG),with 21 cases(42 eyes)in each group.The three groups received BTX-A,micro-acupoint ear acupuncture,and a combination of both treatments,respectively.All three groups were observed for six months.The onset time and duration of efficacy were recorded for each group.The self-rating anxiety scale(SAS)and self-rating depression scale(SDS)scores were measured before and after treatment,and the data were statistically analyzed.RESULTS(1)Onset time and duration of efficacy of BEB:There were statistically significant differences in onset time among the three groups(F=5.058,P=0.012).Compared to the ear acupuncture group,both the botulinum toxin group and the combined treatment group had significantly shorter onset times(tBTG=3.193,P=0.003;tCTG=3.835,P=0.000).There was no statistically significant difference in onset time between the combined treatment group and the botulinum toxin group(P>0.05).There were statistically significant differences in the duration of efficacy among the three groups(F=29.079,P=0.000).Compared to the ear acupuncture group,both the botulinum toxin group and the combined treatment group had significantly longer durations of efficacy(tBTG=4.391,tCTG=7.729,both P=0.000).The duration of efficacy in the combined treatment group was significantly longer than in the botulinum toxin group(t=2.638,P=0.012).(2)SDS scores:The SDS scores of all three groups significantly decreased after treatment(tEAG=4.498,tBTG=5.758,tCTG=11.489,all P=0.000).There were statistically significant differences among the three groups after treatment(F=5.343,P=0.007).The combined treatment group had significantly lower SDS scores compared to the ear acupuncture group and botulinum toxin group(tEAG=3.284,P=0.002;tBTG=2.252,P=0.030).There were no statistically significant differences in SDS scores between the botulinum toxin group and the ear acupuncture group(P＞0.05).(3)SAS scores:The SAS scores of all three groups significantly decreased after treatment(tEAG=4.603,tBTG=7.617,tCTG=10.585,all P=0.000).There were statistically significant differences among the three groups after treatment(F=14.845,P=0.000).The botulinum toxin group and the combined treatment group had significantly lower post-treatment SAS scores compared to the ear acupuncture group(tBTG=2.351,P=0.024;tCTG=5.446,P=0.000).The combined treatment group had significantly lower SAS scores compared to the botulinum toxin group(t=3.070,P=0.004).(4)Clinical efficacy of BEB:The total effective rate for the ear acupuncture group,the botulinum toxin group,and the combined treatment group were 66.7%,76.2%and 95.2%,respectively.There was statistically significant differences in the total effective rate among the three group(χ2=10.855,P=0.004).The total effective rate of the botulinum toxin group compared to the ear acupuncture group was not statistically significant(P>0.05),while the total effective rate of the combined treatment group was significantly higher than both the ear acupuncture group and the botulinum toxin group(χ2EAG=11.118,P=0.001;χ2BTG=6.222,P=0.013).(5)Incidence of adverse reactions:There was no statistically significant differences in the adverse reaction rate among the three groups(P>0.05).CONCLUSIONS Micro-acupoint ear acupuncture combined with BTX-A injection for treating BEB has a rapid onset,long-lasting efficacy,fewer adverse reactions,and significantly improves symptoms of anxiety and depression.It is worthy of clinical promotion.
benign essential blepharospasmbotulinum toxin type Aorbicularis oculi musclemicro-acupoint ear acupunctureanxiety and depression
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